ANDROGEN RECEPTOR

ANDROGEN RECEPTOR

S-T-E-D-T-A-E-Y-S-P-F-K-G-G-Y-T-K

This product is specific for Androgen Receptor (AR). Dihydrotestosterone (DHT) binds with highest affinity to AR and together with testosterone promotes AR transcriptional activity thereby ensuring the development and maintenance of male reproductive functions. AR homodimers recruit a variety of factors including coactivators and mediator proteins whose enzymatic activities promote chromatin remodeling and transcriptional regulation of target genes leading to cell differentiation survival and proliferation. Mutated AR is strongly implicated in development of prostate adenocarcinoma and metastases development. AR mutations can also cause spinal bulbar muscular atrophy (Kennedy disease) and partial/ complete androgen insensitivity. IHC: This product does not require protein digestion pre-treatment or antigen retrieval using heat treatment prior to staining of paraffin sections.

Phosphate buffered saline pH 7. 2

The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Activated but not phosphorylated by HIPK3.

Nucleus.

Phosphorylated in prostate cancer cells in response to several growth factors including EGF. Phosphorylation is induced by c-Src kinase (CSK). Tyr-514 is one of the major phosphorylation sites and an increase in phosphorylation and Src kinase activity is associated with prostate cancer progression (By similarity).

Transcriptional activity is enhanced by binding to RANBP9.

Contains 1 nuclear receptor DNA-binding domain.