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NMDAR NR1 C2\'

NMDAR NR1 C2\'

ArtNr	18-783-75655
Hersteller	GENWAY
Menge	0,025 mg
Typ	Antibody
Applikationen	WB
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-BE8292
Similar products	18-783-75655
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Genway ID:	GWB-BE8292
Specificity:	NMDAR NR1 C2\'
Specificity:	NMDAR NR1 C2\'
Immunogen:	Synthetic peptide from rat NMDA receptor NR1 subunit containing the C2\' splice variant insert.
Antiserum Preparation:	Antisera to rat NMDA receptor. NR1 subunit. splice variant C2\' were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
Preservative Stabilisers:		None present Reconstitution: Reconstitute with 50ul phosphate buffered salineProduct
Note:	Care should be taken during reconstitution as the protein may appear as a film at the bottom of the vial. It\' s recommended that the vial is gently mixed after reconstitution. For long term storage the addition of 0. 09% sodium azide is recommended. N. B. For functional studies do not add azide. Suggested
Dilution:	Western Blot: This product detects a band of approximately 120 kDa in HEK293 cell lysates. Suggested
Dilution:	Western Blotting - 1:1000
Function:	NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. This protein plays a key role in synaptic plasticity synaptogenesis excitotoxicity memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors (By similarity).
Subunit:	Forms heteromeric channel of a zeta subunit (GRIN1) a epsilon subunit (GRIN2A GRIN2B GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B); disulfide-linked. Found in a complex with GRIN2A or GRIN2B GRIN3A or GRIN3B and PPP2CB. Interacts with DLG4 and MPDZ (By similarity).
Subcellular Location:	Cell membrane; Multi-pass membrane protein (By similarity). Cell junction synapse postsynaptic cell membrane (By similarity). Cell junction synapse postsynaptic cell membrane postsynaptic density (By similarity). Note=Enriched in post-synaptic plasma membrane and post-synaptic densities (By similarity).
Ptm:	NMDA is probably regulated by C-terminal phosphorylation of an isoform of NR1 by PKC. Dephosphorylated on Ser-897 probably by protein phosphatase 2A (PPP2CB). Its phosphorylated state is influenced by the formation of the NMDAR-PPP2CB complex and the NMDAR channel activity (By similarity).
Similarity:	Belongs to the glutamate-gated ion channel (TC 1. A. 10) family [view classification]. 1. Ishii. T. et al. (1993) Molecular characterization of the family of the N-Methyl-D-Aspartate receptor subunits. 2. Ehlers. M. D. et al. (1998) Splice variant-specific interaction of the NMDA receptor subunit NR1 with neuronal intermediate filaments.

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Menge: 0,025 mg

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