EGF R


ArtNr	18-783-75623
Hersteller	GENWAY
Menge	0.05 mg
Kategorie	Oncology Antibodies Western Blot ELISA Primary Antibodies By Organ Breast Cancer
Typ	Antibody
Applikationen	WB, ELISA
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-2F9F55
Similar products	18-783-75623
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Genway ID:	GWB-2F9F55
Specificity:	EGF R
Specificity:	EGF R
Immunogen:	Synthetic peptide corresponding to amino acids 1189-1199 of human EGF receptor protein.
Specificity Note:	This product detects human epidermal growth factor receptor (EGFR) a 170kD transmembrane glycoprotein which is a member of the ErbB family of receptor tyrosine kinases. EGFR is the cell surface receptor for members of the EGF family and functions in early embryonic development and in the renewal of stem cells in tissues such as the skin liver and gut. Mutations to EGFR have been found in many human carcinomas including breast brain lung and colon. Over-expression of more than one member of the ErbB family was found to have a negative synergistic effect on patient outcome.
Antiserum Preparation:	Antisera to EGF receptor were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.
Buffer Solution:	Phosphate buffered saline pH7. 2
Preservative Stabilisers:		0. 01%Sodium Azide (NaN3) Suggested
Dilution:	Western Blot: This product detects a band of approximately 170kDa in A431 cell lysates. Suggested
Dilution:	ELISA - 1:8000 - 1:32000Western Blotting - 1:500 - 1:5000
Function:	Receptor for EGF but also for other members of the EGF family as TGF-alpha amphiregulin betacellulin heparin-binding EGF-like growth factor GP30 and vaccinia virus growth factor. Is involved in the control of cell growth and differentiation.
Function:	Isoform 2/truncated isoform may act as an antagonist.
Catalytic Activity:	ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
Subunit:	Binds RIPK1. CBL interacts with the autophosphorylated C-terminal tail of the EGF receptor. Part of a complex with ERBB2 and either PIK3C2A or PIK3C2B. The autophosphorylated form interacts with PIK3C2B maybe indirectly. Interacts with PELP1.
Subcellular Location:	Cell membrane; Single-pass type I membrane protein.
Subcellular Location:	Isoform 2: Secreted.
Tissue Specificity:	Expressed in placenta. Isoform 2 is also expressed in ovarian cancers.
Ptm:	Phosphorylation of Ser-695 is partial and occurs only if Thr-693 is phosphorylated.
Ptm:	Monoubiquitinated and polyubiquitinated upon EGF stimulation; which does not affect tyrosine kinase activity or signaling capacity but may play a role in lysosomal targeting. Polyubiquitin linkage is mainly through \' Lys-63\' but linkage through \' Lys-48\' \' Lys-11\' and \' Lys-29\' also occur.
Disease:	Defects in EGFR are associated with lung cancer [MIM:211980].
Miscellaneous:	Binding of EGF to the receptor leads to dimerization internalization of the EGF-receptor complex induction of the tyrosine kinase activity stimulation of cell DNA synthesis and cell proliferation.
Similarity:	Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
Similarity:	Contains 1 protein kinase domain. 1. Sebastian. S. et al. (2006) The complexity of targeting EGFR signalling in cancer: from expression to turnover. 2. Normanno. N. et al. (2006) Epidermal growth factor receptor (EGFR) signaling in cancer.

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Menge: 0.05 mg

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Lieferung vsl. bis 27.09.2024

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