NUMB


ArtNr	18-783-313076
Hersteller	GENWAY
Menge	0,1 mg
Typ	Antibody
Applikationen	WB, ELISA
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-9F376B
Similar products	18-783-313076
Lieferbar
Genway ID:	GWB-9F376B
Specificity:	NUMB
Specificity:	NUMB
Immunogen:	Peptide sequence C-PFSSDLQKTFEIEL corresponding to the C-Terminal region of NUMB (NP_001005743. 1; 001005744. 1; NP_003735; NP_001005745. 1).
Specificity Note:	This product specifically recognises an epitope within the C-terminal (CT) region of NUMB (protein numb homolog) a membrane-associated protein selectively partitioned during asymmetric cell division involved in the fate of cells during development. NUMB originally identified in Drosophila is a major regulator of the intercellular Notch signalling pathway particularly associated with the development/differentiation of cell lineages of the central nervous system. Studies indicate that inhibition of Notch signalling by NUMB allows for neuronal cell differentiation whereas those cells maintaining Notch signalling initiate apoptosis.
Antiserum Preparation:	Antiserum to human NUMB (CT) was raised by repeated immunisation of goats with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
Buffer Solution:	Phosphate buffered saline pH7. 3
Preservative Stabilisers:		0. 02% Sodium Azide (NaN3) 0. 5% Bovine Serum Albumin Suggested
Dilution:	Western Blot: This product detects a band of approximately 80kDa in mouse brain cell lysates. Suggested
Dilution:	ELISA - 1:16000Western Blotting - 0. 3 - 1. 0ug/ml
Function:	Implicated in the control of cell fate decisions during development.
Subunit:	Interacts with EPS15 LNX and NOTCH1. May interact with DUOXA1. Interacts with RALBP1 in a complex also containing EPN1 and TFAP2A during interphase and mitosis.
Subcellular Location:	Membrane; Peripheral membrane protein.
Ptm:	Isoform 1 and isoform 2 are ubiquitinated by LNX leading to their subsequent proteasomal degradation (By similarity). Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation.
Similarity:	Contains 1 PID domain.

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Menge: 0,1 mg

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Lieferung vsl. bis 30.08.2024

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