Sheep anti Factor H (Beta 1H)

Sheep

Factor H (Beta 1H)

Polyclonal Antibodies to Platelets and Hemostasis Antigens

Glycine buffered saline pH 7. 4Applications Notes : Suitable for use in a variety of gel techniques including radial immunodiffusion (RID) double diffusion immunoelectrophoresis (IEP). The use of 3% PEG 6000 with 1. 2% agarose in a suitable buffer (such as TBE or tris-barbital pH > 8. 2) is recommended. Suitability for use in nephelometry enzyme-linked immunosorbent assays and Western blot and IHC has not been assessed but use in such assays should not necessarily be excluded. Each laboratory should determine an optimum working titer for use in its particular application. . RID : 1ul antiserum/cm2 gel vs. 5ul neat - 1:10 dilution human plasma. . Double Dif

This product contains sodium azide which has been classified as Xn (Harmful) in European Directive 67/548/EEC in the concentration range of 0. 1â ??1. 0%. When disposing of this reagent through lead or copper plumbing flush with copious volumes of water to prevent azide build-up in drains. Sheep anti Factor H (Beta 1H). Sheep Antibody to Human Factor H (Beta 1H)

Secreted.

Genetic variations in CFH are associated with basal laminar drusen [MIM:126700]; also known as drusen of Bruch membrane or cuticular drusen or grouped early adult-onset drusen. Drusen are extracellular deposits that accumulate below the retinal pigment epithelium on Bruch membrane. Basal laminar drusen refers to an early adult-onset drusen phenotype that shows a pattern of uniform small slightly raised yellow subretinal nodules randomly scattered in the macula. In later stages these drusen often become more numerous with clustered groups of drusen scattered throughout the retina. In time these small basal laminar drusen may expand and ultimately lead to a serous pigment epithelial detachment of the macula that may result in vision loss.

Defects in CFH are a cause of hemolytic-uremic syndrome (HUS) [MIM:235400]. HUS is a microvasculature disorder leading to microangiopathic hemolytic anemia associated with distorted erythrocytes (\' burr cells\' ) thrombocytopenia and acute renal failure. Both dominant and recessive modes of inheritance have been reported. Most cases of HUS are associated with epidemics of diarrhea caused by verocytotoxin-producing bacteria but atypical cases of HUS not associated with diarrhea (aHUS) also occur.

Contains 20 Sushi (CCP/SCR) domains.