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Rabbit anti PAK2 (NT)

Rabbit anti PAK2 (NT)

Catalytic
ArtNr	18-511-244849
Hersteller	GENWAY
Menge	0,1 mg
Kategorie	Oncology Metabolism Diabetes Antibodies Western Blot Primary Antibodies By Organ Uterine, Ovarian & Cervical Cancer
Typ	Antibody
Applikationen	WB
Specific against	other
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-AF382F
Similar products	18-511-244849
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Genway ID:	GWB-AF382F
Host Animal:	Rabbit
Immunogen:	Synthetic peptide corresponding to 14 amino acids near the amino terminus of human PAK2 (Genbank accession No. NP_002568)
Specificity:	p21 Activated Kinase 2 (PAK2) N-terminal
Specificity:	Reacts to the N-terminal of human mouse and rat PAK2. The p21-activated kinases (PAKs) are serine-threonine kinases that bind to the active forms of Cdc42 and Rac (1). Of the six PAK proteins only PAK2 is ubiquitously expressed and cleaved by caspase-3. This cleavage removes the amino-terminal regulatory domain and generates a constitutively active kinase fragment(2).
Type of Product:	Polyclonal Antibodies to Enzymes
Concentration:	Lot specificPreservatives: NaN3
Buffer:	PBSApplications Notes : Suitable for use in Western blot (0. 5?1ug/ml). Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.
Warning:	This product contains sodium azide which has been classified as Xn (Harmful) in European Directive 67/548/EEC in the concentration range of 0. 1â ??1. 0%. When disposing of this reagent through lead or copper plumbing flush with copious volumes of water to prevent azide build-up in drains. Rabbit anti PAK2 (NT). Rabbit Antibody to Human p21-activated kinase 2 (PAK2) N-terminal
Function:	The activated kinase acts on a variety of targets. Phosphorylates ribosomal protein S6 histone H4 and myelin basic protein. Full length PAK 2 stimulates cell survival and cell growth. The process is at least in part mediated by phosphorylation and inhibition of pro-apoptotic BAD. Caspase-activated PAK-2p34 is involved in cell death response probably involving the JNK signaling pathway. Cleaved PAK-2p34 seems to have a higher activity than the CDC42-activated form.
Activity:	ATP + a protein = ADP + a phosphoprotein.
Enzyme Regulation:	Activated by binding small G proteins. Binding of GTP-bound CDC42 or RAC1 to the autoregulatory region releases monomers from the autoinhibited dimer enables phosphorylation of Thr-402 and allows the kinase domain to adopt an active structure (By similarity). Following caspase cleavage autophosphorylted PAK-2p34 is constitutively active.
Subunit:	Interacts tightly with GTP-bound but not GDP-bound CDC42/p21 and RAC1. Interacts with SH3MD4. Interacts with and activated by HIV-1 Nef. PAK-2p34 interacts with ARHGAP10.
Subcellular Location:	Serine/threonine-protein kinase PAK 2: Cytoplasm.
Subcellular Location:	PAK-2p34: Nucleus. Cytoplasm perinuclear region. Membrane; Lipid-anchor. Note=Interaction with ARHGAP10 probably changes PAK-2p34 location to cytoplasmic perinuclear region. Myristoylation changes PAK-2p34 location to the membrane.
Tissue Specificity:	Ubiquitously expressed. Higher levels seen in skeletal muscle ovary thymus and spleen.
Ptm:	Full length PAK 2 is autophosphorylated when activated by CDC42/p21. Following cleavage both peptides PAK-2p27 and PAK-2p34 become highly autophosphorylated with PAK-2p27 being phosphorylated on serine and PAK-2p34 on threonine residues respectively. Autophosphorylation of PAK-2p27 can occur in the absence of any effectors and is dependent on phosphorylation of Thr-402 because PAK-2p27 is acting as an exogenous substrate.
Ptm:	During apoptosis proteolytically cleaved by caspase-3 or caspase-3-like proteases to yield active PAK-2p34.
Ptm:	Ubiquitinated leading to its proteosomal degradation.
Ptm:	PAK-2p34 is myristoylated.
Similarity:	Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
Similarity:	Contains 1 CRIB domain.
Similarity:	Contains 1 protein kinase domain.

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