Goat anti Synphilin-1 (C-term)

GWB-53511C

Synthetic Peptide: 829SLELNGEKDKDKGRTLQRT847

Amino acid sequence 829-847 of human synphilin-1 protein.

Not determinedPreservatives: NaN3

This product contains sodium azide which has been classified as Xn (Harmful) in European Directive 67/548/EEC in the concentration range of 0. 1â ??1. 0%. When disposing of this reagent through lead or copper plumbing flush with copious volumes of water to prevent azide build-up in drains. Goat anti-Synphilin-1 (C-term). Goat Antibody to Synphilin-1 C-terminal

Widely expressed with highest levels in brain heart and placenta.

Defects in SNCAIP are a cause of Parkinson disease (PD) [MIM:168600]. PD is a complex multifactorial disorder that typically manifests after the age of 50 years although early-onset cases (before 50 years) are known. PD generally arises as a sporadic condition but is occasionally inherited as a simple mendelian trait. Although sporadic and familial PD are very similar inherited forms of the disease usually begin at earlier ages and are associated with atypical clinical features. PD is characterized by bradykinesia resting tremor muscular rigidity and postural instability as well as by a clinically significant response to treatment with levodopa. The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins) in surviving neurons in various areas of the brain.

Contains 6 ANK repeats.