Somatostatin receptor type 2

GWB-65C694

Receptor for somatostatins-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. In RIN-5F cells this receptor inhibits calcium entry by suppressing voltage dependent calcium-channels.

Membrane; multi-pass membrane protein.

Belongs to the G-protein coupled receptor 1 family [view classification]. Summary: Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR2 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in cerebrum and kidney. [1] Csaba Z. Pirker S. Lelouvier B. Simon A. Videau C. Epelbaum J. Czech T. Baumgartner C. Sperk G. and Dournaud P. Somatostatin receptor type 2 undergoes plastic changes in the human epileptic dentate gyrus[2] Liu A. M. and Wong Y. H. et al. Activation of nuclear factor {kappa}B by somatostatin type 2 receptor in pancreatic acinar AR42J cells involves G{alpha}14 and multiple signaling components: a mechanism requiring protein kinase C calmodulin-dependent kinase II ERK and c-Src[3] Filopanti M. Ronchi C. Ballare E. Bondioni S. Lania A. G. Losa M. Gelmini S. Peri A. Orlando C. Beck-Peccoz P. and et al. Analysis of somatostatin receptors 2 and 5 polymorphisms in patients with acromegaly[4] Chen L. Liu Q. Qin R. Le H. Xia R. Li W. and Kumar M. et al. Amplification and functional characterization of MUC1 promoter and gene-virotherapy via a targeting adenoviral vector expressing hSSTR2 gene in MUC1-positive Panc-1 pancreatic cancer cells in vitro[5] Grant M. Collier B. and Kumar U. et al. Agonist-dependent dissociation of human somatostatin receptor 2 dimers: a role in receptor trafficking[6] Yamada Y. Post S. R. Wang K. Tager H. S. Bell G. I. Seino S. Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain gastrointestinal tract and kidney. [7] Petersenn S. Rasch A. C. Presch S. Beil F. U. Schulte H. M. Genomic structure and transcriptional regulation of the human somatostatin receptor type 2. [8] Kopatz S. A. Aronstam R. S. Sharma S. V. Isolation of complete coding sequence for somatostatin receptor 2 (SSTR2). [9] Suwa M. Sato T. Okouchi I. Arita M. Futami K. Matsumoto S. Tsutsumi S. Aburatani H. Asai K. Akiyama Y. et al. Genome-wide discovery and analysis of human seven transmembrane helix receptor genes. [10] Kalnine N. Chen X. Rolfs A. Halleck A. Hines L. Eisenstein S. Koundinya M. Raphael J. Moreira D. Kelley T. et al. Cloning of human full-length CDSs in BD Creator(TM) system donor vector.