Beta-3 adrenergic receptor

GWB-64C902

Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis.

Expressed mainly in adipose tissues.

Belongs to the G-protein coupled receptor 1 family [view classification]. Summary: The ADRB3 gene product beta-3-adrenergic receptor is located mainly in adipose tissue and is involved in the regulation of lipolysis and thermogenesis. Beta adrenergic receptors are involved in the epenephrine and norepinephrine-induced activation of adenylate cyclase through the action of G proteins. [1] Mattevi V. S. Zembrzuski V. M. and Hutz M. H. et al. Impact of variation in ADRB2 ADRB3 and GNB3 genes on body mass index and waist circumference in a Brazilian population[2] Abu-Amero K. K. Al-Boudari O. M. Mohamed G. H. and Dzimiri N. et al. Beta 3 adrenergic receptor Trp64Arg polymorphism and manifestation of coronary artery disease in Arabs[3] Kasznicki J. Blasiak J. Majsterek I. Przybylowska K. and Drzewoski J. The Trp64Arg beta3-adrenergic receptor amino-acid variant is not associated with overweight and type 2 diabetes mellitus in Polish population[4] Masuo K. Katsuya T. Fu Y. Rakugi H. Ogihara T. and Tuck M. L. et al. Beta2- and beta3-adrenergic receptor polymorphisms are related to the onset of weight gain and blood pressure elevation over 5 years[5] Ellsworth D. L. Coady S. A. Chen W. Srinivasan S. R. Boerwinkle E. and Berenson G. S. Interactive effects between polymorphisms in the beta-adrenergic receptors and longitudinal changes in obesity[6] Emorine L. J. Marullo S. Briend-Sutren M. -M. Patey G. Tate K. Delavier-Klutchko C. Strosberg A. D. Molecular characterization of the human beta 3-adrenergic receptor. [7] van Spronsen A. Nahmias C. Krief S. Briend-Sutren M. -M. Strosberg A. D. Emorine L. J. The promoter and intron/exon structure of the human and mouse beta 3-adrenergic-receptor genes. [8] Lelias J. M. Kaghad M. Rodriguez M. Chalon P. Bonnin J. Dupre I. Delpech B. Bensaid M. Lefur G. Ferrara P. et al. Molecular cloning of a human beta 3-adrenergic receptor cDNA. [9] Kopatz S. A. Aronstam R. S. Sharma S. V. cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www. cdna. org). [10] Rieder M. J. Johanson E. J. da Ponte S. H. Hastings N. C. Ahearn M. O. Bertucci C. B. Wong M. W. Yi Q. Nickerson D. A. SeattleSNPs. NHLBI HL66682 program for genomic applications UW-FHCRC Seattle WA (URL: http://pga. gs. washington. edu).