G-protein coupled receptor protein

GWB-29B39D

Membrane; multi-pass membrane protein (By similarity). Summary: The cysteinyl leukotrienes LTC4 LTD4 and LTE4 are important mediators of human bronchial asthma. Pharmacologic studies have determined that cysteinyl leukotrienes activate at least 2 receptors the protein encoded by this gene and CYSLTR1. This encoded receptor is a member of the superfamily of G protein-coupled receptors. It seems to play a major role in endocrine and cardiovascular systems. [1] Uzonyi B. Lotzer K. Jahn S. Kramer C. Hildner M. Bretschneider E. Radke D. Beer M. Vollandt R. Evans J. F. et al. Cysteinyl leukotriene 2 receptor and protease-activated receptor 1 activate strongly correlated early genes in human endothelial cells[2] Corrigan C. Mallett K. Ying S. Roberts D. Parikh A. Scadding G. and Lee T. Expression of the cysteinyl leukotriene receptors cysLT(1) and cysLT(2) in aspirin-sensitive and aspirin-tolerant chronic rhinosinusitis[3] Hui Y. Cheng Y. Smalera I. Jian W. Goldhahn L. G. A. and Funk C. D. Directed vascular expression of human cysteinyl leukotriene 2 receptor modulates endothelial permeability and systemic blood pressure[4] Fukai H. Ogasawara Y. Migita O. Koga M. Ichikawa K. Shibasaki M. Arinami T. and Noguchi E. Association between a polymorphism in cysteinyl leukotriene receptor 2 on chromosome 13q14 and atopic asthma[5] Pillai S. G. Cousens D. J. Barnes A. A. Buckley P. T. Chiano M. N. Hosking L. K. Cameron L. A. Fling M. E. Foley J. J. Green A. et al. A coding polymorphism in the CYSLT2 receptor with reduced affinity to LTD4 is associated with asthma[6] Ina K. Urakawa I. Mizutani S. Okazaki H. Probable G-protein coupled receptor. [7] Strausberg R. L. Feingold E. A. Grouse L. H. Derge J. G. Klausner R. D. Collins F. S. Wagner L. Shenmen C. M. Schuler G. D. Altschul S. F. et al. Generation and initial analysis of more than 15 000 full-length human and mouse cDNA sequences. [8] Fukai H. Ogasawara Y. Migita O. Koga M. Ichikawa K. Shibasaki M. Arinami T. Noguchi E. Association between a polymorphism in cysteinyl leukotriene receptor 2 on chromosome 13q14 and atopic asthma.