P2Y purinoceptor 14

C-terminal domain of human. Synthetic peptide - KLH conjugated.
Uses: WB IHC (4 ug/ml) ICC (Optimal dilution to be determined by the researcher)

Membrane; multi-pass membrane protein.

Belongs to the G-protein coupled receptor 1 family [view classification]. [1] Moore D. J. Murdock P. R. Watson J. M. Faull R. L. Waldvogel H. J. Szekeres P. G. Wilson S. Freeman K. B. and Emson P. C. GPR105 a novel Gi/o-coupled UDP-glucose receptor expressed on brain glia and peripheral immune cells is regulated by immunologic challenge: possible role in neuroimmune function[2] Skelton L. Cooper M. Murphy M. and Platt A. et al. Human immature monocyte-derived dendritic cells express the G protein-coupled receptor GPR105 (KIAA0001 P2Y14) and increase intracellular calcium in response to its agonist uridine diphosphoglucose[3] Lee B. C. Cheng T. Adams G. B. Attar E. C. Miura N. Lee S. B. Saito Y. Olszak I. Dombkowski D. Olson D. P. Hancock J. et al. P2Y-like receptor GPR105 (P2Y14) identifies and mediates chemotaxis of bone-marrow hematopoietic stem cells[4] Abbracchio M. P. Boeynaems J. M. Barnard E. A. Boyer J. L. Kennedy C. Miras-Portugal M. T. King B. F. Gachet C. et al. Characterization of the UDP-glucose receptor (re-named here the P2Y14 receptor) adds diversity to the P2Y receptor family[5] Joensuu T. Hamalainen R. Yuan B. Johnson C. Tegelberg S. Gasparini P. Zelante L. Pirvola U. Pakarinen L. Lehesjoki A. E. et al. Mutations in a novel gene with transmembrane domains underlie Usher syndrome type 3[6] Joensuu T. Haemaelaeinen R. Yuan B. Johnson C. Tegelberg S. Gasparini P. Zelante L. Pirvola U. Pakarinen L. Lehesjoki A. -E. et al. Mutations in a novel gene with transmembrane domains underlie Usher syndrome type 3. [7] Nomura N. Miyajima N. Sazuka T. Tanaka A. Kawarabayasi Y. Sato S. Nagase T. Seki N. Ishikawa K. Tabata S. et al. Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. [8] Strausberg R. L. Feingold E. A. Grouse L. H. Derge J. G. Klausner R. D. Collins F. S. Wagner L. Shenmen C. M. Schuler G. D. Altschul S. F. et al. Generation and initial analysis of more than 15 000 full-length human and mouse cDNA sequences. [9] Chambers J. K. Macdonald L. E. Sarau H. M. Ames R. S. Freeman K. Foley J. J. Zhu Y. McLaughlin M. M. Murdock P. McMillan L. et al. A G protein-coupled receptor for UDP-glucose.