Probable G-protein coupled receptor 37

N-terminal extracellular domain of human. Synthetic peptide - KLH conjugated.
Uses: IHC (1 ug/ml) (Optimal dilution to be determined by the researcher)

Forms a complex with PARK2 STUB1 and HSP70. The amount of STUB1 in the complex increases during ER stress. STUB1 promotes the dissociation of HSP70 from PARK2 thus facilitating PARK2-mediated GPR37 ubiquitination. Interacts with PACRG.

Expressed in brain and spinal cord and at lower levels in testis placenta and liver but no detectable expression observed in any other tissue. When overexpressed cells tends to become insoluble and unfolded. Accumulation of the unfolded protein may lead to dopaminergic neuronal death in juvenile Parkinson disease (PDJ).

Belongs to the G-protein coupled receptor 1 family [view classification]. [1] Imai Y. Soda M. Murakami T. Shoji M. Abe K. and Takahashi R. et al. A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death[2] Scherer S. W. Cheung J. MacDonald J. R. Osborne L. R. Nakabayashi K. Herbrick J. A. Carson A. R. Parker-Katiraee L. et al. Human chromosome 7: DNA sequence and biology[3] Yang Y. Nishimura I. Imai Y. Takahashi R. and Lu B. et al. Parkin suppresses dopaminergic neuron-selective neurotoxicity induced by Pael-R in Drosophila[4] Imai Y. Soda M. Hatakeyama S. Akagi T. Hashikawa T. Nakayama K. I. and Takahashi R. CHIP is associated with Parkin a gene responsible for familial Parkinson\' s disease and enhances its ubiquitin ligase activity[5] Imai Y. Soda M. Inoue H. Hattori N. Mizuno Y. and Takahashi R. et al. An unfolded putative transmembrane polypeptide which can lead to endoplasmic reticulum stress is a substrate of Parkin[6] Marazziti D. Golini E. Gallo A. Lombardi M. S. Matteoni R. Tocchini-Valentini G. P. Cloning of GPR37 a gene located on chromosome 7 encoding a putative G-protein-coupled peptide receptor from a human frontal brain EST library. [7] Donohue P. J. Shapira H. Mantey S. A. Hampton L. L. Jensen R. T. Battey J. F. A human gene encodes a putative G protein-coupled receptor highly expressed in the central nervous system. [8] Zeng Z. Su K. Kyaw H. Li Y. A novel endothelin receptor type-B-like gene enriched in the brain. [9] Imai Y. Soda M. Inoue H. Hattori N. Mizuno Y. Takahashi R. An unfolded putative transmembrane polypeptide which can lead to endoplasmic reticulum stress is a substrate of Parkin. [10] Hillier L. W. Fulton R. S. Fulton L. A. Graves T. A. Pepin K. H. Wagner-McPherson C. Layman D. Maas J. Jaeger S. Walker R. et al. The DNA sequence of human chromosome 7.