Sphingosine 1-phosphate receptor Edg-6

C-terminal domain of human. Synthetic peptide - KLH conjugated.
Uses: IHC (8 - 19 ug/ml) (Optimal dilution to be determined by the researcher)

Membrane; multi-pass membrane protein.

Belongs to the G-protein coupled receptor 1 family [view classification]. Summary: This protein is a member of the endothelial differentiation G-protein-coupled (EDG)) receptor gene family. EDG receptors bind lysophospholipids or lysosphingolipids as ligands and are involved in cell signalling in many different cell types. This EDG receptor gene is intronless and is specifically expressed in the lymphoid tissue. [1] Holdsworth G. Osborne D. A. Pham T. T. Fells J. I. Hutchinson G. Milligan G. and Parrill A. L. A single amino acid determines preference between phospholipids and reveals length restriction for activation of the S1P4 receptor[2] Graler M. H. Grosse R. Kusch A. Kremmer E. Gudermann T. and Lipp M. The sphingosine 1-phosphate receptor S1P4 regulates cell shape and motility via coupling to Gi and G12/13[3] Vogler R. Sauer B. Kim D. S. Schafer-Korting M. and Kleuser B. et al. Sphingosine-1-phosphate and its potentially paradoxical effects on critical parameters of cutaneous wound healing[4] Contos J. J. Ye X. Sah V. P. and Chun J. et al. Tandem genomic arrangement of a G protein (Gna15) and G protein-coupled receptor (s1p(4)/lp(C1)/Edg6) gene[5] Candelore M. R. Wright M. J. Tota L. M. Milligan J. Shei G. J. Bergstrom J. D. and Mandala S. M. Phytosphingosine 1-phosphate: a high affinity ligand for the S1P(4)/Edg-6 receptor[6] Graeler M. H. Bernhardt G. Lipp M. EDG6 a novel G protein-coupled receptor related to receptors for bioactive lysophospholipids is specifically expressed in lymphoid tissue. [7] Kopatz S. A. Aronstam R. S. Sharma S. V. cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www. cdna. org). [8] Strausberg R. L. Feingold E. A. Grouse L. H. Derge J. G. Klausner R. D. Collins F. S. Wagner L. Shenmen C. M. Schuler G. D. Altschul S. F. et al. Generation and initial analysis of more than 15 000 full-length human and mouse cDNA sequences. [9] Yamazaki Y. Kon J. Sato K. Tomura H. Sato M. Yoneya T. Okazaki H. Okajima F. Ohta H. Edg-6 as a putative sphingosine 1-phosphate receptor coupling to Ca(2+) signaling pathway. [10] Van Brocklyn J. R. Graeler M. H. Bernhardt G. Hobson J. P. Lipp M. Spiegel S. Sphingosine-1-phosphate is a ligand for the G protein-coupled receptor EDG-6.