IL6

GWB-C10E83

Highly purified recombinant murine IL-6

Product code recognizes murine IL-6.

Secreted

From polyclonal serum Storage

For ELISA: Use at a concentration of 0. 5 µ g/ml. For FuncS: Use at a concentration of 0. 24-0. 36 ng/ml. For WB: Use at a concentration of 0. 1-0. 2 µ g/ml. Not tested in other applications. Optimal dilutions/concentrations should be determined by the researcher. Interleukin 6 (IL-6) is a pluripotent 20-22 kDa cytokine that plays a role in the pathophysiology of severe infection and regulates the immune response acute phase reaction and hematopoiesis. IL-6 plays a critical role in B-cell differentiation to plasma cells and is a potent growth factor for plasmacytoma and myeloma. Continuous IL-6 gene expression makes an essential contribution to a multistep oncogenesis of plasma cell neoplasia. IL-6 is a very useful culture supplement for the generation of a high number of antibody-producing hybridomas.

Secreted.

Genetic variations in IL6 may be correlated with bone mineral density (BMD). Low BMD is a risk factor for osteoporotic fracture. Osteoporosis is characterized by reduced bone mineral density disrutption of bone microarchitecture and the alteration of the amount and variety of non-collagenous proteins in bone. Osteoporotic bones are more at risk of fracture.

At least 1 polymorphism in the IL6 gene renders HIV-infected men susceptible to Kaposi sarcoma [MIM:148000]. Kaposi sarcoma is a sarcoma of spindle cells mixed with angiomatous tissue. A relatively rare malignant skin tumor that results in multifocal purplish coloured papules or plaques that eventually form nodules. Most commonly seen in patients who suffer from AIDS.