RFC4

ArtNr	18-272-197225
Hersteller	GENWAY
Menge	0.05 ml
Kategorie	Oncology Antibodies Western Blot Primary Antibodies By Organ Bladder Cancer
Typ	Antibody
Applikationen	WB
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-B01400
Similar products	18-272-197225
Lieferbar
Genway ID:	GWB-B01400
Isotype:	IgG
Immunogen:	Synthetic peptide (Human) - which represented a portion of human Replication Factor C 437 kDa subunit encoded in part by exons 10 and 11.
Antigen Species:	Human
Positive Control:	HeLa cell nuclear extract
Target:	RFC4
Concentration:	1 mg/ml Storage
Buffer:	Tris-citrate/phosphate pH 7-8 0. 1% sodium azide
Application Note:	WB: Use at a dilution of 1/500 - 1/5000. Predicted
Molecular Weight:	37 kDa. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. Human Replication Factor C (RFC) is a hetero-pentameric protein consisting of the p140 p40 p38 p37 and p36 subunits. RFC functions in the loading of the DNA polymerase delta processivity factor (PCNA Proliferating Cell nuclear Antigen) onto a primed DNA template during DNA synthesis and repair. RFC may also participate in the DNA damage checkpoint response with a PCNA-like hetero-trimer consisting of Hus 1 Rad 1 and Rad 9.
Function:	The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. This subunit may be involved in the elongation of the multiprimed DNA template.
Subunit:	Heterotetramer of subunits RFC2 RFC3 RFC4 and RFC5 that can form a complex either with RFC1 or with RAD17. The former interacts with PCNA in the presence of ATP while the latter has ATPase activity but is not stimulated by PCNA.
Subcellular Location:	Nucleus (Probable).
Miscellaneous:	Despite of the presence of a putative ATP-binding motif this protein does not bind ATP.
Similarity:	Belongs to the activator 1 small subunits family.

Hinweis: Die dargestellten Informationen und Dokumente (Bedienungsanleitung, Produktdatenblatt, Sicherheitsdatenblatt und Analysezertifikat) entsprechen unserem letzten Update und sollten lediglich der Orientierung dienen. Wir übernehmen keine Garantie für die Aktualität. Für spezifische Anforderungen bitten wir Sie, uns eine Anfrage zu stellen.

Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Arbeitsanleitung (Data Sheet) anfordern

Produkdatenblatt anfordern

Sicherheitsdatenblatt anfordern

Einfache Bestellung Periodische Bestellung

Menge: 0.05 ml

lieferbar

Lieferung vsl. bis 30.08.2024

Express-Lieferung: 14 Tage sparen

Vergleichen

Auf den Wunschzettel

Weiterempfehlen per Mail