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PSCA (ready-to-use)

PSCA (ready-to-use)

ArtNr	18-272-196279
Hersteller	GENWAY
Menge	7 ml
Kategorie	Oncology Antibodies Immunohistochemistry Primary Antibodies By Organ Colorectal Cancer
Typ	Antibody
Applikationen	IHC
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-205408
Similar products	18-272-196279
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Genway ID:	GWB-205408
Isotype:	IgG
Immunogen:	Synthetic peptide (Human) (extracellular).
Antigen Species:	Human
Positive Control:	Bladder carcinoma and Prostate carcinoma
Target:	PSCA
Localization:	Plasma membrane Storage
Buffer:	PBS pH 7. 4 containing 1%BSA and 0. 1% sodium azide
Application Note:	IHC-P: Use at an assay dependent dilution. Perform heat mediated antigen retrieval before commencing with IHC staining protocol. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. Cellular
Localization:	Plasma membrane PSCA (Prostate Stem Cell antigen) is a cell surface antigen which is overexpressed in ~40% of primary prostate cancers and in as many as 100% of metastatic ones. PSCA is also overexpressed in a majority of transitional cell and pancreatic carcinomas. Antibody directed against PSCA inhibits tumorigenesis slows tumor growth prolongs survival and prevents metastasis in a preclinical zenograft model indicating that PSCA may have utility as a prognostic marker and/or therapeutic target in prostate cancer.
Function:	May be involved in the regulation of cell proliferation. Has a cell-proliferation inhibition activity in vitro.
Subcellular Location:	Cell membrane; Lipid-anchor GPI-anchor.
Tissue Specificity:	Highly expressed in prostate (basal secretory and neuroendocrine epithelium cells). Also found in bladder (transitional epithelium) placenta (trophoblasts) stomach (neuroendocrine cells) colon (neuroendocrine cells) and kidney (collecting ducts). Overexpressed in prostate cancers and expression is correlated with tumor stage grade and androgen-independence. Highly expressed in prostate cancer bone metastases. Expressed in gastric epithelial cells mainly in the isthmus (at protein level). Not detected in normal intestinal epithelium (at protein level).
Induction:	Down-regulated in gastric cancer cells.
Polymorphism:	Genetic variations in PSCA may influence susceptibility to diffuse-type gastric cancer.
Similarity:	Contains 1 UPAR/Ly6 domain.

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Menge: 7 ml

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