LHX3

ArtNr	18-272-196209
Hersteller	GENWAY
Menge	0.05 mg
Kategorie	Antibodies Immunohistochemistry Immunoprecipitation Western Blot Immunofluorescence Immunocytochemistry Primary Antibodies
Typ	Antibody
Applikationen	WB, IF, IP, IHC, ICC
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-D5702D
Similar products	18-272-196209
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Genway ID:	GWB-D5702D
Isotype:	IgG
Immunogen:	C-terminal portion of mouse LHX3 protein.
Antigen Species:	Mouse
Specificity:	This product recognizes LHX3 and does not appear to crossreact with gsh4 on tissue sections.
Target:	LHX3
Localization:	Nuclear
Concentration:	0. 5 mg/ml Storage
Preservative:	0. 1% Sodium Azide; Constituents: PBS. pH 7. 2
Application Note:	ICC: Use at a dilution of 1/100 - 1/250. IF: Use at an assay dependent dilution. Use a secondary antibody conjugated to biotin and then streptavidin-conjugated to fluorochrome. IHC-P: Use at a dilution of 1/125 - 1/500. IHC-Fr: 1:1500-1:3000. For whole mounts recommended fixative is MEMFA using a dilution of 1/2000 - 1/4000. IP: Use at a dilution of 1/100. WB: Use at a dilution of 1/1250 - 1/2500. Predicted
Molecular Weight:	44 kDa. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. Cellular
Localization:	Nuclear The pituitary gland releases hormones that regulate growth lactation homeostasis the stress response reproductive development and fitness as well as water metabolism. LHX3 is one of several transcription factors that have been implicated in pituitary development. This particular transcription factor is critical for motor neuron specification and the development of the anterior and intermediate lobes of the pituitary gland in mammals. The sequence of the human LHX3 gene has been identified and characterized by IU researchers.
Function:	Binds to and activates the promoter of the alpha-glycoprotein gene and synergistically enhances transcription from the prolactin promoter in cooperation with Pit-1 (By similarity).
Subcellular Location:	Nucleus (Probable).
Disease:	Defects in LHX3 are a cause of combined pituitary hormone deficiency (CPHD) [MIM:262600]; also known as pituitary dwarfism III. CPHD is characterized by a complete deficit in all but one (adrenocorticotropin) anterior pituitary hormone and a rigid cervical spine leading to limited head rotation.
Similarity:	Contains 1 homeobox DNA-binding domain.
Similarity:	Contains 2 LIM zinc-binding domains.

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