DR6

GWB-3F2228

Synthetic peptide corresponding to amino acids 371 - 655 of Human DR6.

HeLa whole-cell extract

Cell Membrane

Affinity chromatography. Storage

WB: Use at a concentration of 1 - 2 µ g/ml. Detects a band of approximately 66 kDa (predicted

Cell Membrane Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors TNFR1 and Fas. Several novel death receptors including DR3 DR4 and DR5 were recently identified. A new death domain containing receptor in the TNFR family was cloned recently and termed DR6 for death receptor 6. Like TNFR1 DR6 interacts with death domain containing adapter molecule TRADD. Overexpression of DR6 induces apoptosis and activates NF-kB and JNK. DR6 is widely expressed inhuman tissues and cell lines. The ligand for DR6 hasnot been identified.

Associates with TRADD.

Highly expressed in heart brain placenta pancreas lymph node thymus and prostate. Detected at lower levels in lung skeletal muscle kidney testis uterus small intestine colon spleen bone marrow and fetal liver. Very low levels were found in adult liver and peripheral blood leukocytes.

Contains 4 TNFR-Cys repeats.