Neuroligin 1

GWB-3873D0

Peptide with sequence C-TAKQDDPKQQ from the internal region of th Notes: Peptide ELISA: antibody detection limit dilution 1:4 000. Western Blot: Preliminary experiments gave an approx 150kDa band in Human Brain lysates after 1ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 92. 0 kDa according to NP_055747. 1. The 150kDa band was successfully blocked by incubation with the immunizing peptide. Summary: This protein is a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. [provided by RefSeq]. [1] Cronin S. Tomik B. Bradley D. G. Slowik A. and Hardiman O. et al. Screening for replication of genome-wide SNP associations in sporadic ALS[2] Gratacos M. Costas J. de Cid R. Bayes M. Gonzalez J. R. Baca-Garcia E. de Diego Y. Fernandez-Aranda F. et al. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment[3] Li X. Zhang J. Cao Z. Wu J. and Shi Y. et al. Solution structure of GOPC PDZ domain and its interaction with the C-terminal motif of neuroligin[4] Muzny D. M. Scherer S. E. Kaul R. Wang J. Yu J. Sudbrak R. Buhay C. J. Chen R. Cree A. Ding Y. Dugan-Rocha S. Gill R. et al. The DNA sequence annotation and analysis of human chromosome 3[5] Ylisaukko-oja T. Rehnstrom K. Auranen M. Vanhala R. Alen R. Kempas E. Ellonen P. Turunen J. A. Makkonen I. Riikonen R. et al. Analysis of four neuroligin genes as candidates for autism