Snurportin1

Peptide with sequence SHSPDHPGCLMEN from the C Terminus of the protein sequence according to NP_005692. Notes: Peptide ELISA: antibody detection limit dilution 1:2 000. Western Blot: Preliminary experiments gave no signal but low background in Hela and Human Brain extracts at up to 1ug/ml. Summary: The nuclear import of the spliceosomal snRNPs U1 U2 U4 and U5 is dependent on the presence of a complex nuclear localization signal. The latter is composed of the 5\' -2 2 7-terminal trimethylguanosine (m3G) cap structure of the U snRNA and the Sm core domain. The protein encoded by this gene interacts specifically with m3G-cap and functions as an snRNP-specific nuclear import receptor. Alternatively spliced transcript variants encoding the same protein have been identified for this gene. [1] Ospina J. K. Gonsalvez G. B. Bednenko J. Darzynkiewicz E. Gerace L. and Matera A. G. Cross-talk between snurportin1 subdomains[2] Stelzl U. Worm U. Lalowski M. Haenig C. Brembeck F. H. Goehler H. Stroedicke M. Zenkner M. Schoenherr A. Koeppen S. et al. A human protein-protein interaction network: a resource for annotating the proteome[3] Strasser A. Dickmanns A. Luhrmann R. and Ficner R. et al. Structural basis for m3G-cap-mediated nuclear import of spliceosomal UsnRNPs by snurportin1[4] Yong J. Wan L. and Dreyfuss G. et al. Why do cells need an assembly machine for RNA-protein complexes?[5] Narayanan U. Ospina J. K. Frey M. R. Hebert M. D. and Matera A. G. et al. SMN the spinal muscular atrophy protein forms a pre-import snRNP complex with snurportin1 and importin beta