KPNA1 / Importin alpha 5

06-202-339528 - Immunizing Peptide

1-3ug/ml. Summary: Recombination activating proteins RAG1 and RAG2 regulate and mediate V(D)J recombination the process by which genes for immunoglobulins and T-cell receptors are generated. Several other ubiquitously expressed proteins are thought to be recruited in the recombination process. Among these are the genes affected in severe combined immune deficiency and genes involved in ds-DNA break repair. The KPNA1 product interacts with RAG1 and may play a role in V(D)J recombination. [1] Melen K. Fagerlund R. Franke J. Kohler M. Kinnunen L. and Julkunen I. Importin alpha nuclear localization signal binding sites for STAT1 STAT2 and influenza A virus nucleoprotein[2] Krichevsky A. Graessmann A. Nissim A. Piller S. C. Zakai N. and Loyter A. Antibody fragments selected by phage display against the nuclear localization signal of the HIV-1 Vpr protein inhibit nuclear import in permeabilized and intact cultured cells[3] Dvorin J. D. Bell P. Maul G. G. Yamashita M. Emerman M. and Malim M. H. Reassessment of the roles of integrase and the central DNA flap in human immunodeficiency virus type 1 nuclear import[4] Limon A. Devroe E. Lu R. Ghory H. Z. Silver P. A. and Engelman A. et al. Nuclear localization of human immunodeficiency virus type 1 preintegration complexes (PICs): V165A and R166A are pleiotropic integrase mutants primarily defective for integration not PIC nuclear import[5] Fagerlund R. Melen K. Kinnunen L. and Julkunen I. et al. Arginine/lysine-rich nuclear localization signals mediate interactions between dimeric STATs and importin alpha 5