SMARCB1 / SNF5 / INI1

GWB-2909B2

Peptide with sequence MMMALSKTFGQKP-C from the N Terminus of the Notes: Peptide ELISA: antibody detection limit dilution 1:16 000. Western Blot: Approx. 45kDa and 55-60kDa bands observed in 293 lysate at 0. 5ug of primary. Please note that currently we cannot find an explanation in the literature for the additional band we observe at 55-60kDa. Summary: The protein encoded by this gene is part of a complex that relieves repressive chromatin structures allowing the transcriptional machinery to access its targets more effectively. The encoded nuclear protein may also bind to and enhance the DNA joining activity of HIV-1 integrase. This protein has been found to be a tumor suppressor and mutations in it have been associated with malignant rhabdoid tumors. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]. [1] Kohashi K. Izumi T. Oda Y. Yamamoto H. Tamiya S. Taguchi T. Iwamoto Y. Hasegawa T. and Tsuneyoshi M. Infrequent SMARCB1/INI1 gene alteration in epithelioid sarcoma: a useful tool in distinguishing epithelioid sarcoma from malignant rhabdoid tumor[2] Chbani L. Guillou L. Terrier P. Decouvelaere A. V. Gregoire F. Terrier-Lacombe M. J. Ranchere D. Robin Y. M. Collin F. et al. Epithelioid sarcoma: a clinicopathologic and immunohistochemical analysis of 106 cases from the French sarcoma group[3] Swensen J. J. Keyser J. Coffin C. M. Biegel J. A. Viskochil D. H. and Williams M. S. Familial occurrence of schwannomas and malignant rhabdoid tumour associated with a duplication in SMARCB1[4] Wu X. Dagar V. Algar E. Muscat A. Bandopadhayay P. Ashley D. and Wo Chow C. Rhabdoid tumour: a malignancy of early childhood with variable primary site histology and clinical behaviour[5] McKenna E. S. Sansam C. G. Cho Y. J. Greulich H. Evans J. A. Thom C. S. Moreau L. A. Biegel J. A. Pomeroy S. L. and Roberts C. W. Loss of the epigenetic tumor suppressor SNF5 leads to cancer without genomic instability