PPP2R5E

GWB-24F5DD

Peptide with sequence C-LKRGLRRDGIIPT from the C Terminus of the Notes: Western blot: Approx 55kDa and 40kDa bands seen in mouse brain extracts. Recommended for use at 0. 5-2ug/ml. Please note that the two bands may correspond to two different isoforms. Two isoforms of the epsilon mRNA have been detected in Northern blots (J Biol Chem 1996 Sep 6; 271(36):22081-9). Summary: The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme which is composed of a catalytic subunit and a constant regulatory subunit that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This protein is an epsilon isoform of the regulatory subunit B56 subfamily. [provided by RefSeq]. [1] Sablina A. A. Chen W. Arroyo J. D. Corral L. Hector M. Bulmer S. E. DeCaprio J. A. and Hahn W. C. The tumor suppressor PP2A Abeta regulates the RalA GTPase[2] Dozier C. Bonyadi M. Baricault L. Tonasso L. and Darbon J. M. et al. Regulation of Chk2 phosphorylation by interaction with protein phosphatase 2A via its B\' regulatory subunit[3] Colland F. Jacq X. Trouplin V. Mougin C. Groizeleau C. Hamburger A. Meil A. Wojcik J. Legrain P. and Gauthier J. M. Functional proteomics mapping of a human signaling pathway[4] Hrimech M. Yao X. J. Branton P. E. and Cohen E. A. et al. Human immunodeficiency virus type 1 Vpr-mediated G(2) cell cycle arrest: Vpr interferes with cell cycle signaling cascades by interacting with the B subunit of serine/threonine protein phosphatase 2A[5] Elder R. T. Yu M. Chen M. Zhu X. Yanagida M. and Zhao Y. et al. HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25