FOXP4

GWB-91690A

1:1562500

Suggested starting concentrations are provided. Optimal dilutions should be determined by end-user. Differences in calculated versus apparent molecular weight may be due to post-translational modifications or protein hydrophobicity. Foxp4 is a member of the murine forkhead family of transcription factors. It is expressed exclusively in the epithelial cells of the developing intestine. where. in late development. it is expressed in a gradient along the longitudinal axis of the villi.

Forms homodimers and heterodimers with FOXP1 and FOXP2. Dimerization is required for DNA-binding.

Expressed in the adult heart brain spleen lung liver kidney and testes. Developmental Stage: Expressed predominantly in the lung and brain during embryogenesis. Expressed in the lung epithelium and the mesenchyme immediately adjacent to the epithelium from 10. 5 dpc. At 9. 5 dpc expressed in the foregut endoderm but not in the heart. At 16. 5 and 18. 5 dpc expressed in both the proximal and distal airway epithelium. Also expressed in the developing gut. In the hindgut primarily expressed in epithelial cells of the intestine and stomach. Expressed in the brain in a dynamic pattern. At 14. 5 dpc expressed at high levels in the intermediate zone of the neopallial cortex with lower levels in the surrounding cells. By 16. 5 dpc no longer expressed in the intermediate zone but still present in the surrounding cells of the neopallial cortex.

Contains 1 C2H2-type zinc finger.