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SFRS10 (splicing factor. arginine/serine-rich 10 (transformer 2 homolog. Drosophila))

SFRS10 (splicing factor. arginine/serine-rich 10 (transformer 2 homolog. Drosophila))

ArtNr	18-003-43596
Hersteller	GENWAY
Menge	0.1 mg
Kategorie	Antibodies Immunohistochemistry Western Blot Primary Antibodies
Typ	Antibody
Applikationen	WB, IHC
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-D07755
Similar products	18-003-43596
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Genway ID:	GWB-D07755
Antigen Specificity:	Polyclonal antibody produced in rabbits immunized with a synthetic peptide corresponding to a region of Human SFRS10. Western Blot: Suggested dilution at 1. 25 microg/ml in 5% skim milk / PBS buffer. and HRP conjugated anti-Rabbit IgG should be diluted in 1: 50. 000 - 100. 000 as second antibody.
ELISA Titre:	1:62500
Category:	RNA Binding Proteins
Note:	Suggested starting concentrations are provided. Optimal dilutions should be determined by end-user. Differences in calculated versus apparent molecular weight may be due to post-translational modifications or protein hydrophobicity. SFRS10 contains 1 RRM (RNA recognition motif) domain and belongs to the splicing factor SR family. It is a sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing.
Function:	Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing.
Subunit:	Interacts with SAFB/SAFB1 (By similarity). Found in a pre-mRNA exonic splicing enhancer (ESE) complex with SFRS10 SNRP70 SNRPA1 and SRRM1. Binds to A3 enhancer proteins SFRS4 SFRS5 SFRS6 and SFRS9. Interacts with CPSF6 RNPS1 and phosphorylated FUSIP1.
Subcellular Location:	Nucleus.
Tissue Specificity:	Highest expression in heart skeletal muscle and pancreas. Less abundant in kidney placenta and brain. Lowest expression in kidney and liver.
Ptm:	Phosphorylated in the RS domains.
Ptm:	Arg-241 is dimethylated probably to asymmetric dimethylarginine.
Similarity:	Belongs to the splicing factor SR family.
Similarity:	Contains 1 RRM (RNA recognition motif) domain. Helmken. C. . (2003) Hum. Genet. 114 (1). 11-21.

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