RNF2 (ring finger protein 2)

GWB-39D1B1

1:312500

E3 ubiquitin-protein ligase that mediates monoubiquitination of \' Lys-119\' of histone H2A thereby playing a central role in histone code and gene regulation. H2A \' Lys-119\' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. May be involved in the initiation of both imprinted and random X inactivation. Essential component of the Polycomb group (PcG) multiprotein PRC1 complex a complex required to maintain the transcriptionally repressive state of many genes including Hox genes throughout development. PcG PRC1 complex act via chromatin remodeling and modification of histones rendering chromatin heritably changed in its expressibility. Acts as the main E3 ubiquitin ligase on histone H2A of the PRC1 complex while RING1 and BMI1/PCGF4 may rather act as a modulator of RNF2/RING2 activity.

Component of some chromatin-associated Polycomb complex (PcG). Part of the E2F6. com-1 complex in G0 phase composed of E2F6 MGA MAX TFDP1 CBX3 BAT8 EUHMTASE1 RING1 RNF2/RING2 MBLR L3MBTL2 and YAF2. Component of chromatin-associated class II PcG repressive complex 1 (PRC1/hPRC-H) at least composed of PCGF2/RNF110 BMI1/PCGF4 CBX2/M33 CBX4/PC2 CBX8/PC3 PHC1 PHC2 PHC3 SCMH1 RING1 and RNF2/RING2. Interacts with RYBP HIP2 and TFCP2. Association to the chromosomal DNA is cell-cycle dependent.

Contains 1 RING-type zinc finger. Summary: Polycomb group (PcG) of proteins form the multiprotein complexes that are important for the transcription repression of various genes involved in development and cell proliferation. The protein encoded by this gene is one of the PcG proteins. It has been shown to interact with and suppress the activity of transcription factor CP2 (TFCP2/CP2). Studies of the mouse counterpart suggested the involvement of this gene in the specification of anterior-posterior axis as well as in cell proliferation in early development. This protein was also found to interact with huntingtin interacting protein 2 (HIP2) an ubiquitin-conjugating enzyme and possess ubiquitin ligase activity. Voncken. J. W. . et al. . (2003) Proc Natl Acad Sci U. S. A. 4 100(5). 2468-73.