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RAX (retina and anterior neural fold homeobox)

RAX (retina and anterior neural fold homeobox)

ArtNr	18-003-42112
Hersteller	GENWAY
Menge	0.05 mg
Kategorie	Antibodies Immunohistochemistry Western Blot Primary Antibodies
Typ	Antibody
Applikationen	WB, IHC
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-2D61E7
Similar products	18-003-42112
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Genway ID:	GWB-2D61E7
Antigen Specificity:	Polyclonal antibody produced in rabbits immunized with a synthetic peptide corresponding to a region of human RAX.
ELISA Titre:	1:12500
Note:	Suggested starting concentrations are provided. Optimal dilutions should be determined by end-user. Differences in calculated versus apparent molecular weight may be due to post-translational modifications or protein hydrophobicity. RAX (retinal homeobox protein Rx) is a member of homeobox family of transcription factors. Mutations in mouse and fish Rax lead to defects in retinal development and result in animal models of anophthalmia.
Function:	Plays a critical role in eye formation by regulating the initial specification of retinal cells and/or their subsequent proliferation. Binds to the photoreceptor conserved element-I (PCE-1/Ret 1) in the photoreceptor cell-specific arrestin promoter.
Subcellular Location:	Nucleus.
Tissue Specificity:	Expressed in the developing eye and weakly expressed in the adult retina.
Disease:	Defects in RAX are the cause of isolated microphthalmia type 3 (MCOP3) [MIM:611038]. Microphthalmia is a clinically heterogeneous disorder of eye formation ranging from small size of a single eye to complete bilateral absence of ocular tissues. Microphthalmia is a significant cause of congenital blindness.
Similarity:	Belongs to the paired homeobox family. Bicoid subfamily.
Similarity:	Contains 1 homeobox DNA-binding domain.
Similarity:	Contains 1 OAR domain. Voronina. V. A. . et al. . (2004) Hum. Mol. Genet. 13(3). 315-322.

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