Gamma-aminobutyric-acid receptor alpha-6 subunit

Peptide representing a sequence that is specific for the a6-subunit of rat GABAA Receptor. Peptide antigen has no homology with any other GABAA R-subunit.

GABA the major inhibitory neurotransmitter in the vertebrate brain mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.

Membrane; multi-pass membrane protein.

Belongs to the ligand-gated ionic channel (TC 1. A. 9) family [view classification]. Summary: GABAA receptor subunit; part of a cerebellar receptor subtype selective for antagonist of alcohol-induced motor incoordination and ataxia [RGD]. [1] Santhakumar V. Hanchar H. J. Wallner M. Olsen R. W. and Otis T. S. et al. Contributions of the GABAA receptor alpha6 subunit to phasic and tonic inhibition revealed by a naturally occurring polymorphism in the alpha6 gene[2] Saba L. Porcella A. Sanna A. Congeddu E. Marziliano N. Mongeau R. Grayson D. and Pani L. Five mutations in the GABA A alpha6 gene 5\' flanking region are associated with a reduced basal and ethanol-induced alpha6 upregulation in mutated Sardinian alcohol non-preferring rats[3] Fisher J. L. et al. The alpha 1 and alpha 6 subunit subtypes of the mammalian GABA(A) receptor confer distinct channel gating kinetics[4] Carr L. G. Spence J. P. Peter Eriksson C. J. Lumeng L. and Li T. K. et al. AA and ANA rats exhibit the R100Q mutation in the GABAA receptor alpha 6 subunit[5] Wisden W. and Seeburg P. H. et al. GABAA receptor channels: from subunits to functional entities[6] Lueddens H. Pritchett D. Khler M. Killisch I. Keinaenen K. Monyer H. Sprengel R. Seeburg P. H. Cerebellar GABAA receptor selective for a behavioural alcohol antagonist.