RABBIT F(ab\&#039,)2 ANTI MOUSE CD194

CD194

KHPO4 pH7. 4

Synthetic peptide DTTQDETVYNSYYFYESMP-C corresponding to amino acids 8-26 of mouse CD194.

High affinity receptor for the C-C type chemokines CCL17/TARC and CCL22/MDC. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Could play a role in lipopolysaccharide (LPS)-induced endotoxic shock. In the CNS could mediate hippocampal-neuron survival. Ref. 3Subcellular locationCell membrane; Multi-pass membrane protein. Tissue specificityExpressed in the thymus macrophages and T- and B-cells. Developmental stageLow expression at 7. 5 dpc and 12. 5 dpc in the yolk sac. Post-translational modificationIn natural killer cells CCL22 binding induces phosphorylation on yet undefined Ser/Thr residues most probably by beta-adrenergic receptor kinases 1 and 2 By similarity. Sequence similaritiesBelongs to the G-protein coupled receptor 1 family.