Rat Anti-Mouse CD23 (FceRII)

GWB-68A085

2G8

CD23 low affinity IgE Fc receptor The CD23 antigen is the low affinity IgE Fc receptor which is a 49 kDa protein with 38 and 28 kDa fragments. 1 It is expressed on most mature conventional B cells (but not on peritoneal CD5+ B cells) and can also be found on the surface of T cells macrophages and platelets. 1-6 It is distinct from the high affinity IgE receptors found on basophils and mast cells which mediate allergic reactions. The low affinity receptors are thought to play a role in isotype specific immunoregulation. 3 The regulation of CD23 surface expression appears to be integral with the complex IgE system which involves interactions of cells cytokines antibodies and regulatory factors. 2-6 CD23 has been described as a ?membrane bound cytokine \" in that the soluble cleavage products of CD23 are themselves able to act as cytokines in vitro. 6.

Flow Cytometry: 0. 1 ug/106 cells

Contains 1 C-type lectin domain. 1. Rao M. W. Lee and D. Conrad. 1987. J. Immunol. 138:1845. 2. Cong Y. Z. Rabin E. and Wortis H. H. 1991. International Immunology. 3:467. 3. Conrad DH. 1991. Monographs in Allergy. 29:9. 4. Vercelli D. and Geha RS. 1989. Annals of Allergy. 63:4. 5. Yu P. Kosco-Vilbios M. Richards M. Kohler G. and Lamers M. C. 1994. Nature 369:753. 6. Bonnefoy J. -Y. Lecoanet-Henchoz S. Aubry J. P. Gauchat J. F. and Graber P. 1995. Current Opinions in Immunol. 7:355.