RAT ANTI MOUSE CD104:Biotin

CD104

Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant

Recognises mouse integrin beta 4 (CD104) a 200kD glycoprotein that can associate with integrin alpha 6 (CD49f) to form a heterodimer on the cell surface. Expression of CD104 is localised to the basal region of a wide variety of epithelial cells. In mice CD104 is also expressed on peripheral neurones carcinoma cell lines and a subset of endothelial cells. The alpha 6 beta 4 (CD49f/CD104) integrin has been identified as a component of hemidesmosomes in stratified squamous epithelium where it plays an important role in the adhesion of epithelia to basement membrane. Studies suggest that the CD49f/CD104 integrin is involved in cell matrix adhesion but expression of the CD49f/CD104 integrin in endothelial cells is thought to have a different function. Recommended Secondary Antibodies: STREPTAVIDIN

The fibronectin type-III-like domains bind BPAG1 and plectin and probably also recruit BP230 By similarity. Sequence similaritiesBelongs to the integrin beta chain family. Contains 1 Calx-beta domain. Contains 4 fibronectin type-III domains. Contains 1 PSI domain. Contains 1 VWFA domain. 1. Coghlin C. et al. (2006) Characterization and over-expression of chaperonin t-complex proteins in colorectal cancer. J Pathol. 210:351-357. 2. Fislová T. et al. (2010) Association of the Influenza Virus RNA Polymerase Subunit PB2 with the Host Chaperonin CCT J Virol. 84: 8691-9. [1] \" Maturation of human cyclin E requires the function of eukaryotic chaperonin CCT. \" Won K. -A. Schumacher R. J. Farr G. W. Horwich A. L. Reed S. I. Mol. Cell. Biol. 18:7584-7589(1998) [PubMed: 9819444] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA]. [2] \" Isolation and expression of a human novel cDNA homologous to the beta subunit of mouse CCT (chaperonin-containing TCP-1). \" Xin Y. Yu L. Bi A. Fan Y. Dai F. Zhang M. Zhang Q. Zhao S. Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [MRNA]. [3] \" Cloning of human full-length CDSs in BD Creator(TM) system donor vector. \" Kalnine N. Chen X. Rolfs A. Halleck A. Hines L. Eisenstein S. Koundinya M. Raphael J. Moreira D. Kelley T. LaBaer J. Lin Y. Phelan M. Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. [4] \" Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201). \" Ebert L. Schick M. Neubert P. Schatten R. Henze S. Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. [5] \" The status quality and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). \" The MGC Project TeamGenome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain. [6] Adams M. D. Loftus B. J. Zhou L. Phillips C. Brandon R. Fuhrmann J. Kim U. J. Kerlavage A. R. Venter J. C. Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-217. [7] \" Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. \" Gevaert K. Goethals M. Martens L. Van Damme J. Staes A. Thomas G. R. Vandekerckhove J. Nat. Biotechnol. 21:566-569(2003) [PubMed: 12665801] [Abstract]Cited for: PROTEIN SEQUENCE OF 2-20. Tissue: Platelet. [8] Bienvenut W. V. Potts A. Quadroni M. Submitted (MAY-2004) to UniProtKBCited for: PROTEIN SEQUENCE OF 2-13 ACETYLATION AT ALA-2 MASS SPECTROMETRY. Tissue: B-cell lymphoma. [9] Lubec G. Afjehi-Sadat L. Chen W. -Q. Sun Y. Submitted (DEC-2008) to UniProtKBCited for: PROTEIN SEQUENCE OF 26-40; 58-72; 83-131; 139-154; 157-170; 182-189; 192-203; 205-222; 237-250; 285-342; 348-354; 359-402; 406-427; 432-441; 445-466; 482-500 AND 502-516 MASS SPECTROMETRY. Tissue: Brain Cajal-Retzius cell and Fetal brain cortex. [10] \" A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death. \" Imai Y. Soda M. Murakami T. Shoji M. Abe K. Takahashi R. J. Biol. Chem. 278:51901-51910(2003) [PubMed: 14532270] [Abstract]Cited for: INTERACTION WITH PACRG.