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RAT ANTI MOUSE CD23

ArtNr 20-783-315083
Hersteller GENWAY
Menge 0.02 mg
Kategorie
Typ Antibody
Applikationen IP
Specific against Mouse
Host Rat
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Alias GWB-1BF053
Similar products 20-783-315083
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Genway ID:
GWB-1BF053
Specificity:
CD23
Isotype:
IgG2a
Preparation:
Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution:
Phosphate buffered saline pH7. 4
Preservative Stabilisers:
0. 09% Sodium AzideApprox. Protein Concentrations: IgG concentration 1. 0 mg/ml
Immunogen:
Fc epsilon R isolated from the 01. 2B2 mouse B cell hybridoma.
Specificity:
Recognises murine CD23 which is the 49kD low affinity Fc receptor for IgE (Fc epsilon RII). In the mouse CD23 is primarily expressed on mature B lymphocytes including follicular dendritic cells. CD23 is known to play an important role in IgE binding but reports suggest that CD23 may also be involved in B-cell proliferation and differentiation. Clone B3B4 is reported to block the binding of IgE to Fc epsilon RII (1). Recommended Negative Controls: RAT IgG2a NEGATIVE CONTROLRecommended Secondary Antibodies: Goat Anti Rat IgGRabbit Anti Rat IgGGoat Anti Rat IgG (MOUSE ADSORBED)
Function:
This receptor has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen). Subcellular locationMembrane; Single-pass type II membrane protein. Post-translational modificationN- and O-glycosylated By similarity.
Miscellaneous:
There are two kinds of Fc receptors for IgE which differ in both structure and
Function:
high affinity receptors on basophils and mast cells and low affinity receptors on lymphocytes and monocytes. Sequence similaritiesContains 1 C-type lectin domain. 1. Gerke V. and Moss S. E. (2002) Annexins: From structure to function. Physiol. Rev. 82: 331-371. [1] \" Primary structure of human placental anticoagulant protein. \" Funakoshi T. Hendrickson L. E. McMullen B. A. Fujikawa K. Biochemistry 26:8087-8092(1987) [PubMed: 2964863] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA]. [2] \" Structure and expression of cDNA for an inhibitor of blood coagulation isolated from human placenta: a new lipocortin-like protein. \" Iwasaki A. Suda M. Nakao H. Nagoya T. Saino Y. Arai K. Mizoguchi T. Sato F. Yoshizaki H. Hirata M. Miyata T. Shidara Y. Murata M. Maki M. J. Biochem. 102:1261-1273(1987) [PubMed: 2963810] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] PROTEIN SEQUENCE OF 2-320. [3] \" Cloning and expression of cDNA for human vascular anticoagulant a Ca2+-dependent phospholipid-binding protein. \" Maurer-Fogy I. Reutelingsperger C. P. M. Pieters J. Bodo G. Stratowa C. Hauptmann R. Eur. J. Biochem. 174:585-592(1988) [PubMed: 2455636] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] PARTIAL PROTEIN SEQUENCE. [4] \" Cloning and expression of cDNA for human endonexin II a Ca2+ and phospholipid binding protein. \" Kaplan R. Jaye M. Burgess W. H. Schlaepfer D. D. Haigler H. T. J. Biol. Chem. 263:8037-8043(1988) [PubMed: 2967291] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA]. [5] \" Five distinct calcium and phospholipid binding proteins share homology with lipocortin I. \" Pepinsky R. B. Tizard R. Mattaliano R. J. Sinclair L. K. Miller G. T. Browning J. L. Chow E. P. Burne C. Huang K. -S. Pratt D. Wachter L. Hession C. Frey A. Z. Wallner B. P. J. Biol. Chem. 263:10799-10811(1988) [PubMed: 2968983] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA]. [6] \" Characterization of cDNA encoding human placental anticoagulant protein (PP4): homology with the lipocortin family. \" Grundmann U. Abel K. -J. Bohn H. Loebermann H. Lottspeich F. Kuepper H. Proc. Natl. Acad. Sci. U. S. A. 85:3708-3712(1988) [PubMed: 2967495] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA]. [7] \" The gene encoding human annexin V has a TATA-less promoter with a high G+C content. \" Fernandez M. -P. Morgan R. O. Fernandez M. R. Carcedo M. -T. Gene 149:253-260(1994) [PubMed: 7958998] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Lung. [8] \" Organization of the human annexin V (ANX5) gene. \" Cookson B. T. Engelhardt S. Smith C. Bamford H. A. Prochazka M. Tait J. F. Genomics 20:463-467(1994) [PubMed: 8034319] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. [9] \" Complete sequencing and characterization of 21 243 full-length human cDNAs. \" Ota T. Suzuki Y. Nishikawa T. Otsuki T. Sugiyama T. Irie R. Wakamatsu A. Hayashi K. Sato H. Nagai K. Kimura K. Makita H. Sekine M. Obayashi M. Nishi T. Shibahara T. Tanaka T. Ishii S. Yamamoto J. Saito K. Kawai Y. Isono Y. Nakamura Y. Nagahari K. Murakami K. Yasuda T. Iwayanagi T. Wagatsuma M. Shiratori A. Sudo H. Hosoiri T. Kaku Y. Kodaira H. Kondo H. Sugawara M. Takahashi M. Kanda K. Yokoi T. Furuya T. Kikkawa E. Omura Y. Abe K. Kamihara K. Katsuta N. Sato K. Tanikawa M. Yamazaki M. Ninomiya K. Ishibashi T. Yamashita H. Murakawa K. Fujimori K. Tanai H. Kimata M. Watanabe M. Hiraoka S. Chiba Y. Ishida S. Ono Y. Takiguchi S. Watanabe S. Yosida M. Hotuta T. Kusano J. Kanehori K. Takahashi-Fujii A. Hara H. Tanase T. -O. Nomura Y. Togiya S. Komai F. Hara R. Takeuchi K. Arita M. Imose N. Musashino K. Yuuki H. Oshima A. Sasaki N. Aotsuka S. Yoshikawa Y. Matsunawa H. Ichihara T. Shiohata N. Sano S. Moriya S. Momiyama H. Satoh N. Takami S. Terashima Y. Suzuki O. Nakagawa S. Senoh A. Mizoguchi H. Goto Y. Shimizu F. Wakebe H. Hishigaki H. Watanabe T. Sugiyama A. Takemoto M. Kawakami B. Yamazaki M. Watanabe K. Kumagai A. Itakura S. Fukuzumi Y. Fujimori Y. Komiyama M. Tashiro H. Tanigami A. Fujiwara T. Ono T. Yamada K. Fujii Y. Ozaki K. Hirao M. Ohmori Y. Kawabata A. Hikiji T. Kobatake N. Inagaki H. Ikema Y. Okamoto S. Okitani R. Kawakami T. Noguchi S. Itoh T. Shigeta K. Senba T. Matsumura K. Nakajima Y. Mizuno T. Morinaga M. Sasaki M. Togashi T. Oyama M. Hata H. Watanabe M. Komatsu T. Mizushima-Sugano J. Satoh T. Shirai Y. Takahashi Y. Nakagawa K. Okumura K. Nagase T. Nomura N. Kikuchi H. Masuho Y. Yamashita R. Nakai K. Yada T. Nakamura Y. Ohara O. Isogai T. Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Neuroblastoma. [10] \" Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201). \" Halleck A. Ebert L. Mkoundinya M. Schick M. Eisenstein S. Neubert P. Kstrang K. Schatten R. Shen B. Henze S. Mar W. Korn B. Zuo D. Hu Y. LaBaer J. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

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Menge: 0.02 mg
Lieferbar: In stock
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