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Mouse CD54 (ICAM-1)

Mouse CD54 (ICAM-1)

ArtNr	20-511-242017
Hersteller	GENWAY
Menge	0.5 mg
Kategorie	Oncology Neuroscience Neural Lineage Markers Antibodies By Cell Type Hematology Myeloma Cell Biology Cell Movement Cell Adhesion Primary Antibodies
Typ	Antibody
Clon	BE29G1
Specific against	Mouse
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-4F2833
Similar products	20-511-242017
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Genway ID:	GWB-4F2833
Isotype:	IgG2a (Rat)
Clone:	BE29G1Host Animal: Rat
Specificity:	CD54. ICAM-1
Type of Product:	Monoclonal Antibodies to Non-Human CDs
Concentration:	0. 5mg/ml (OD280nm)Preservatives: NaN3
Buffer:	0. 01M PBS pH 7. 2 containing 1% BSAApplications Notes : Can be used in flow cytometry immunoprecipitation and immunohistochemistry (frozen sections). We recommend using 1ug to stain 1. 0 x 106 cells in flow cytometric applications. Depending on the particular application some variance can be expected. Suitable for studies of inflammation lymphocyte differentiation and lymphocyte activation. Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.
Warning:	This product contains sodium azide which has been classified as Xn (Harmful) in European Directive 67/548/EEC in the concentration range of 0. 1â ??1. 0%. When disposing of this reagent through lead or copper plumbing flush with copious volumes of water to prevent azide build-up in drains. MAb to Mouse CD54 (ICAM-1). Monoclonal Antibody to Mouse CD54 (ICAM-1)
Function:	ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration ICAM1 engagement promotes the assembly of endothelial apical cups through SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus.
Subunit:	Homodimer (Probable). Interacts with human herpesvirus 8 MIR2 protein (Probable). Interacts with MUC1 and promotes cell aggregation in epithelial cells. Interacts with SGEF. Binds to coxsackievirus A21 capsid proteins and acts as a receptor for this virus.
Subcellular Location:	Membrane; Single-pass type I membrane protein.
Ptm:	Monoubiquitinated which is promoted by MARCH9 and leads to endocytosis.
Polymorphism:	Homozygotes with ICAM1-Kalifi Met-56 seem to have an increased risk for cerebral malaria.
Similarity:	Belongs to the immunoglobulin superfamily. ICAM family.
Similarity:	Contains 5 Ig-like C2-type (immunoglobulin-like) domains.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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Menge: 0.5 mg

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Lieferung vsl. bis 30.08.2024

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