SHEEP ANTI HUMAN PLASMINOGEN:FITC

GWB-29E701

Polyclonal IgGSpecies Cross Reactivity: Reacts with: Cat Rat Dog Bovine Guinea PigN. B. Antibody reactivity and working conditions may vary between species.

Recognises human plasminogen a 92kDa single-chain glycoprotein and inactive precursor (zymogen) of plasmin secreted by the liver and present in the blood and majority of extravascular body fluids. Plasminogen is the central component in the fibrinolytic system and is converted into active plasmin through cleavage by the endogenous activators urokinase (u-PA) and tissue plasminogen activator (t-PA) in the presence of fibrin. The level of plasminogen is maintained in the plasma at around 200mg/L with an increase being associated with hypothyroidism obesity and pregnancy and deficiencies with many disorders including thrombosis liver disease sepsis and hyperthyroidism. 7440-0104F may cross react with plasminogen from other species.

Kringle domains mediate interaction with CSPG4. Ref. 23Post-translational modificationN-linked glycan contains N-acetyllactosamine and sialic acid. O-linked glycans consist of Gal-GalNAc disaccharide modified with up to 2 sialic acid residues (microheterogeneity). In the presence of the inhibitor the activation involves only cleavage after Arg-580 yielding two chains held together by two disulfide bonds. In the absence of the inhibitor the activation involves additionally the removal of the activation peptide. Involvement in diseaseDefects in PLG are a cause of susceptibility to thrombosis (THR) [MIM:188050]. It is a multifactorial disorder of hemostasis characterized by abnormal platelet aggregation in response to various agents and recurrent thrombi formation. Ref. 43Ref. 46Ref. 47Ref. 48Defects in PLG are the cause of plasminogen deficiency (PLGD) [MIM:217090]. PLGD is characterized by decreased serum plasminogen activity. Two forms of the disorder are distinguished: type 1 deficiency is additionally characterized by decreased plasminogen antigen levels and clinical symptoms whereas type 2 deficiency also known as dysplasminogenemia is characterized by normal or slightly reduced antigen levels and absence of clinical manifestations. Plasminogen deficiency type 1 results in markedly impaired extracellular fibrinolysis and chronic mucosal pseudomembranous lesions due to subepithelial fibrin deposition and inflammation. The most common clinical manifestation of type 1 deficiency is ligneous conjunctivitis in which pseudomembranes formation on the palpebral surfaces of the eye progresses to white yellow-white or red thick masses with a wood-like consistency that replace the normal mucosa. Ref. 43Ref. 46Ref. 47Ref. 48Ref. 45Ref. 49Ref. 50Ref. 51Miscellaneous: Plasmin is inactivated by alpha-2-antiplasmin immediately after dissociation from the clot. Sequence similaritiesBelongs to the peptidase S1 family. Plasminogen subfamily. Contains 5 kringle domains. Contains 1 PAN domain. Contains 1 peptidase S1 domain. [1] \" cDNA cloning of the B cell membrane protein CD22: a mediator of B-B cell interactions. \" Wilson G. L. Fox C. H. Fauci A. S. Kehrl J. H. J. Exp. Med. 173:137-146(1991) [PubMed: 1985119] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM CD22-BETA) VARIANT HIS-639. Tissue: Tonsil. [2] \" Genomic structure and chromosomal mapping of the human CD22 gene. \" Wilson G. L. Najfeld V. Kozlow E. Menniger J. Ward D. Kehrl J. H. J. Immunol. 150:5013-5024(1993) [PubMed: 8496602] [Abstract]Cited for: NUCLEOTIDE SEQUENCE (ISOFORMS CD22-ALPHA AND CD22-BETA). [3] \" The B-cell antigen CD22 mediates monocyte and erythrocyte adhesion. \" Stamenkovic I. Seed B. Nature 345:74-77(1990) [PubMed: 1691828] [Abstract]Cited for: NUCLEOTIDE SEQUENCE (ISOFORM CD22-BETA). [4] \" The DNA sequence and biology of human chromosome 19. \" Grimwood J. Gordon L. A. Olsen A. S. Terry A. Schmutz J. Lamerdin J. E. Hellsten U. Goodstein D. Couronne O. Tran-Gyamfi M. Aerts A. Altherr M. Ashworth L. Bajorek E. Black S. Branscomb E. Caenepeel S. Carrano A. V. Caoile C. Chan Y. M. Christensen M. Cleland C. A. Copeland A. Dalin E. Dehal P. Denys M. Detter J. C. Escobar J. Flowers D. Fotopulos D. Garcia C. Georgescu A. M. Glavina T. Gomez M. Gonzales E. Groza M. Hammon N. Hawkins T. Haydu L. Ho I. Huang W. Israni S. Jett J. Kadner K. Kimball H. Kobayashi A. Larionov V. Leem S. -H. Lopez F. Lou Y. Lowry S. Malfatti S. Martinez D. McCready P. M. Medina C. Morgan J. Nelson K. Nolan M. Ovcharenko I. Pitluck S. Pollard M. Popkie A. P. Predki P. Quan G. Ramirez L. Rash S. Retterer J. Rodriguez A. Rogers S. Salamov A. Salazar A. She X. Smith D. Slezak T. Solovyev V. Thayer N. Tice H. Tsai M. Ustaszewska A. Vo N. Wagner M. Wheeler J. Wu K. Xie G. Yang J. Dubchak I. Furey T. S. DeJong P. Dickson M. Gordon D. Eichler E. E. Pennacchio L. A. Richardson P. Stubbs L. Rokhsar D. S. Myers R. M. Rubin E. M. Lucas S. M. Nature 428:529-535(2004) [PubMed: 15057824] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. [5] \" Identification of the gene variations in human CD22. \" Hatta Y. Tsuchiya N. Matsushita M. Shiota M. Hagiwara K. Tokunaga K. Immunogenetics 49:280-286(1999) [PubMed: 10079291] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 13-137; 139-239; 241-328 AND 418-502 VARIANTS THR-34; GLU-152; LYS-203; GLY-664; CYS-669 AND ASP-745. [6] \" Natural ligands of the B cell adhesion molecule CD22 beta carry N-linked oligosaccharides with alpha-2 6-linked sialic acids that are required for recognition. \" Powell L. D. Sgroi D. Sjoberg E. R. Stamenkovic I. Varki A. J. Biol. Chem. 268:7019-7027(1993) [PubMed: 8463235] [Abstract]Cited for: SIALIC ACID-BINDING. [7] \" A role in B cell activation for CD22 and the protein tyrosine phosphatase SHP. \" Doody G. M. Justement L. B. Delibrias C. C. Matthews R. J. Lin J. Thomas M. L. Fearon D. T. Science 269:242-244(1995) [PubMed: 7618087] [Abstract]Cited for: INTERACTION WITH PTPN6. [8] \" Involvement of p72syk kinase p53/56lyn kinase and phosphatidyl inositol-3 kinase in signal transduction via the human B lymphocyte antigen CD22. \" Tuscano J. M. Engel P. Tedder T. F. Agarwal A. Kehrl J. H. Eur. J. Immunol. 26:1246-1252(1996) [PubMed: 8647200] [Abstract]Cited for: INTERACTION WITH LYN; SYK AND PIK3R1/PIK3R2. [9] \" CD22 associates with protein tyrosine phosphatase 1C Syk and phospholipase C-gamma(1) upon B cell activation. \" Law C. L. Sidorenko S. P. Chandran K. A. Zhao Z. Shen S. H. Fischer E. H. Clark E. A. J. Exp. Med. 183:547-560(1996) [PubMed: 8627166] [Abstract]Cited for: INTERACTION WITH PTPN6; SYK AND PLCG1. [10] \" CD22 a B lymphocyte-specific adhesion molecule that regulates antigen receptor signaling. \" Tedder T. F. Tuscano J. Sato S. Kehrl J. H. Annu. Rev. Immunol. 15:481-504(1997) [PubMed: 9143697] [Abstract]Cited for: REVIEW.