Mouse F(ab\&#039,)2 Anti-Human CD19

GWB-A9D13B

SJ25-C1

CD19CD19 is a type I transmembrane glycoprotein and a member of the immunoglobulin superfamily. It is expressed at all stages of B cell differentiation except terminally differentiated plasma cells. It is also present on the cell surface of follicular dendritic cells. CD19 associates with CD21 CD81 Leu 13 and/or MHC Class II molecules to form a signal transduction complex on the B cell surface. This signaling complex modulates the activation threshold for the B cell antigen receptor (BCR). ^1-5

Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin eyes or clothing. Wear eye or face protection when handling. If skin or eye contact occurs wash with copious amounts of water. If ingested or inhaled contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Forms a complex with CD21 CD81 and CD225 in the membrane of mature B cells. Interacts with VAV. Interacts with GRB2 and SOS when phosphorylated on Tyr-348 and/or Tyr-378. Interacts with PLCG2 when phosphorylated on Tyr-409.

Phosphorylated upon DNA damage probably by ATM or ATR.

Contains 2 Ig-like C2-type (immunoglobulin-like) domains. McMichael A. K. P. C. L. Beverly S. Cobbold M. J. Crumpton W. Gilks F. M. Gotch N. Hogg M. Horton N. Ling I. C. M. MacLennan D. Y. Mason C. Milstein D. Spiegelhalter and H. Waldmann eds. 1987. Leukocyte Typing III: White Cell Differentiation Antigens Oxford University Press Oxford. Barclay A. N. M. H. Brown S. K. A. Law A. J. McKnight M. G. Tomlinson and P. A. van der Merwe eds. 1997. The Leukocyte Antigens Facts Book 2nd Edition CD19 Section Academic Press New York p. 179. Tedder T. F. L. J. Zhou and P. Engel. 1994. Immunol. Today 14:437. Fearon D. T. and R. H. Carter. 1995. Annu. Rev. Immunol. 13:127. Doody G. M. P. W. Dempsey and D. T. Fearson. 1996. Curr. Opin. Immunol. 8:378.