Vergleich

MOUSE ANTI HUMAN CD54:RPE

ArtNr 20-783-315403
Hersteller GENWAY
Menge 25 TESTS
Kategorie
Typ Antibody
Specific against Human
Host Mouse
ECLASS 5.1 32160702
ECLASS 6.1 32160702
ECLASS 8.0 32160702
ECLASS 9.0 32160702
ECLASS 10.0.1 32160702
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Alias GWB-FA6A1E
Similar products 20-783-315403
Lieferbar
Genway ID:
GWB-FA6A1E
Specificity:
CD54
Isotype:
IgG1
Buffer Solution:
Phosphate buffered saline pH7. 4
Preservative Stabilisers:
1% Bovine Serum Albumin 0. 09% Sodium AzideApprox. Protein Concentrations: IgG concentration 0. 1 mg/ml
Immunogen:
Human monocytes
Specificity:
Recognises the human CD54 cell surface antigen a 90kD glycoprotein also known as ICAM-1. CD54 is expressed by many cells following activation by inflammatory mediators. Clone 15. 2 is reported to block CD54 function (2). AbD Recommended Negative Controls: MOUSE IgG1 NEGATIVE CONTROL:RPE
Function:
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration ICAM1 engagement promotes the assembly of endothelial apical cups through SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus. Ref. 12Ref. 13Ref. 14Ref. 18Subunit structureHomodimer Probable. Interacts with human herpesvirus 8 MIR2 protein Probable. Interacts with MUC1 and promotes cell aggregation in epithelial cells. Interacts with SGEF. Binds to coxsackievirus A21 capsid proteins and acts as a receptor for this virus. Ref. 14Ref. 18Ref. 15Ref. 27Ref. 28Subcellular locationMembrane; Single-pass type I membrane protein. Post-translational modificationMonoubiquitinated which is promoted by MARCH9 and leads to endocytosis.
Polymorphism:
Homozygotes with ICAM1-Kalifi Met-56 seem to have an increased risk for cerebral malaria. Sequence similaritiesBelongs to the immunoglobulin superfamily. ICAM family. Contains 5 Ig-like C2-type (immunoglobulin-like) domains. 1. Maglione D. et al. (1991) Isolation of a human placenta cDNA coding for a protein related to the vascular permeability factor. P. N. A. S. 88: 9267-9271. [1] \" Isolation of a human placenta cDNA coding for a protein related to the vascular permeability factor. \" Maglione D. Guerriero V. Viglietto G. Delli-Bovi P. Persico M. G. Proc. Natl. Acad. Sci. U. S. A. 88:9267-9271(1991) [PubMed: 1924389] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM PLGF-1). Tissue: Placenta. [2] \" A heparin-binding form of placenta growth factor (PlGF-2) is expressed in human umbilical vein endothelial cells and in placenta. \" Hauser S. D. Weich H. A. Growth Factors 9:259-268(1993) [PubMed: 8148155] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM PLGF-2). Tissue: Placenta. [3] \" Two alternative mRNAs coding for the angiogenic factor placenta growth factor (PlGF) are transcribed from a single gene of chromosome 14. \" Maglione D. Guerriero V. Viglietto G. Ferraro M. G. Aprelikova O. Alitalo K. del Vecchio S. Lei K. -J. Chou J. Y. Persico M. G. Oncogene 8:925-931(1993) [PubMed: 7681160] [Abstract]Cited for: PARTIAL NUCLEOTIDE SEQUENCE (ISOFORM PLGF-2). [4] \" Placenta growth factor: identification and characterization of a novel isoform generated by RNA alternative splicing. \" Cao Y. Ji W. -R. Qi P. Rosin A. Cao Y. Biochem. Biophys. Res. Commun. 235:493-498(1997) [PubMed: 9207183] [Abstract]Cited for: NUCLEOTIDE SEQUENCE (ISOFORM PLGF-3). Tissue: Placenta. [5] \" The DNA sequence and analysis of human chromosome 14. \" Heilig R. Eckenberg R. Petit J. -L. Fonknechten N. Da Silva C. Cattolico L. Levy M. Barbe V. De Berardinis V. Ureta-Vidal A. Pelletier E. Vico V. Anthouard V. Rowen L. Madan A. Qin S. Sun H. Du H. Pepin K. Artiguenave F. Robert C. Cruaud C. Bruels T. Jaillon O. Friedlander L. Samson G. Brottier P. Cure S. Segurens B. Aniere F. Samain S. Crespeau H. Abbasi N. Aiach N. Boscus D. Dickhoff R. Dors M. Dubois I. Friedman C. Gouyvenoux M. James R. Madan A. Mairey-Estrada B. Mangenot S. Martins N. Menard M. Oztas S. Ratcliffe A. Shaffer T. Trask B. Vacherie B. Bellemere C. Belser C. Besnard-Gonnet M. Bartol-Mavel D. Boutard M. Briez-Silla S. Combette S. Dufosse-Laurent V. Ferron C. Lechaplais C. Louesse C. Muselet D. Magdelenat G. Pateau E. Petit E. Sirvain-Trukniewicz P. Trybou A. Vega-Czarny N. Bataille E. Bluet E. Bordelais I. Dubois M. Dumont C. Guerin T. Haffray S. Hammadi R. Muanga J. Pellouin V. Robert D. Wunderle E. Gauguet G. Roy A. Sainte-Marthe L. Verdier J. Verdier-Discala C. Hillier L. W. Fulton L. McPherson J. Matsuda F. Wilson R. Scarpelli C. Gyapay G. Wincker P. Saurin W. Quetier F. Waterston R. Hood L. Weissenbach J. Nature 421:601-607(2003) [PubMed: 12508121] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORM PLGF-1). [6] \" The status quality and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). \" The MGC Project TeamGenome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM PLGF-2). Tissue: Muscle and Placenta. [7] \" Placenta growth factor. Potentiation of vascular endothelial growth factor bioactivity in vitro and in vivo and high affinity binding to Flt-1 but not to Flk-1/KDR. \" Park J. E. Chen H. H. Winer J. Houck K. A. Ferrara N. J. Biol. Chem. 269:25646-25654(1994) [PubMed: 7929268] [Abstract]Cited for: CHARACTERIZATION PROTEIN SEQUENCE OF 19-24. [8] \" The crystal structure of human placenta growth factor-1 (PlGF-1) an angiogenic protein at 2. 0 A resolution. \" Iyer S. Leonidas D. D. Swaminathan G. J. Maglione D. Battisti M. Tucci M. Persico M. G. Acharya K. R. J. Biol. Chem. 276:12153-12161(2001) [PubMed: 11069911] [Abstract]Cited for: X-RAY CRYSTALLOGRAPHY (2. 0 ANGSTROMS) (ISOFORM PLGF-1).

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Menge: 25 TESTS
Lieferbar: In stock
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