MOUSE ANTI HUMAN CD11a:Biotin

CD11a

Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant

Recognises the integrin alphaL subunit a 180kD glycoprotein expressed by all human leucocytes. The molecule is involved in cell-cell adhesion processes and binds to ICAM-1 2 and 3. Recommended Secondary Antibodies: STREPTAVIDIN

The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage. Sequence similaritiesBelongs to the integrin alpha chain family. Contains 7 FG-GAP repeats. Contains 1 VWFA domain. 1. Sandor F. et al. (2003) Importance of extra- and intracellular domains of TLR1 and TLR2 in NFkB signalling. J. Cell. Biol. 162:1099 - 1110. [1] \" Cloning and characterization of two Toll/Interleukin-1 receptor-like genes TIL3 and TIL4: evidence for a multi-gene receptor family in humans. \" Chaudhary P. M. Ferguson C. Nguyen V. Nguyen O. Massa H. F. Eby M. Jasmin A. Trask B. J. Hood L. Nelson P. S. Blood 91:4020-4027(1998) [PubMed: 9596645] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Leukocyte and Prostate. [2] \" A family of human receptors structurally related to Drosophila Toll. \" Rock F. L. Hardiman G. Timans J. C. Kastelein R. A. Bazan J. F. Proc. Natl. Acad. Sci. U. S. A. 95:588-593(1998) [PubMed: 9435236] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA]. [3] \" Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling. \" Yang R. -B. Mark M. R. Gray A. M. Huang A. Xie M. -H. Zhang M. Goddard A. D. Wood W. I. Gurney A. L. Godowski P. J. Nature 395:284-288(1998) [PubMed: 9751057] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] RESPONSE TO LIPOPOLYSACCHARIDE. Tissue: Fetal lung. [4] \" Natural selection in the TLR-related genes in the course of primate evolution. \" Nakajima T. Ohtani H. Satta Y. Uno Y. Akari H. Ishida T. Kimura A. Immunogenetics 60:727-735(2008) [PubMed: 18810425] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA]. [5] Mural R. J. Istrail S. Sutton G. G. Florea L. Halpern A. L. Mobarry C. M. Lippert R. Walenz B. Shatkay H. Dew I. Miller J. R. Flanigan M. J. Edwards N. J. Bolanos R. Fasulo D. Halldorsson B. V. Hannenhalli S. Turner R. Yooseph S. Lu F. Nusskern D. R. Shue B. C. Zheng X. H. Zhong F. Delcher A. L. Huson D. H. Kravitz S. A. Mouchard L. Reinert K. Remington K. A. Clark A. G. Waterman M. S. Eichler E. E. Adams M. D. Hunkapiller M. W. Myers E. W. Venter J. C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. [6] \" The status quality and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). \" The MGC Project TeamGenome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Blood. [7] \" Cloning and sequencing of extracellular domain and its N-terminal and C-terminal fragments of Toll-like receptor 2. \" Zhang L. Yu W. B. Ma Y. Y. Di 4 Jun Yi Da Xue Xue Bao 23:1085-1089(2002)Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-586. [8] \" Cell activation and apoptosis by bacterial lipoproteins through Toll-like receptor-2. \" Aliprantis A. O. Yang R. -B. Mark M. R. Suggett S. Devaux B. Radolf J. D. Klimpel G. R. Godowski P. J. Zychlinsky A. Science 285:736-739(1999) [PubMed: 10426996] [Abstract]Cited for: RESPONSE TO BACTERIAL LIPOPROTEINS. [9] \" A novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling. \" Yamamoto M. Sato S. Mori K. Hoshino K. Takeuchi O. Takeda K. Akira S. J. Immunol. 169:6668-6672(2002) [PubMed: 12471095] [Abstract]Cited for: INTERACTION WITH TICAM1. [10] \" Four N-linked glycosylation sites in human toll-like receptor 2 cooperate to direct efficient biosynthesis and secretion. \" Weber A. N. Morse M. A. Gay N. J. J. Biol. Chem. 279:34589-34594(2004) [PubMed: 15173186] [Abstract]Cited for: GLYCOSYLATION AT ASN-114; ASN-199 AND ASN-442 MUTAGENESIS OF ASN-114; ASN-199; THR-416 AND ASN-442.