MOUSE ANTI HUMAN BAX (N-TERMINAL)

BAX (N-TERMINAL)

Purified IgG prepared by affinity chromatography on Protein A

Human BAX N-terminal region

Accelerates programmed cell death by binding to and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Induces the release of cytochrome c activation of CASP3 and thereby apoptosis. Ref. 1Ref. 4Ref. 12Subunit structureHomodimer. Forms heterodimers with BCL2 E1B 19K protein BCL2L1 isoform Bcl-X(L) MCL1 and A1. Interacts with SH3GLB1 and HN. Interacts with SFN and YWHAZ; the interaction occurs in the cytoplasm. Under stress conditions JNK-mediated phosphorylation of SFN and YWHAZ releases BAX to mitochondria. Isoform Sigma interacts with BCL2A1 and BCL2L1 isoform Bcl-X(L). Interacts with RNF144B which regulates the ubiquitin-dependent stability of BAX. Ref. 1Ref. 4Ref. 14Ref. 15Ref. 16Ref. 19Ref. 20Subcellular locationIsoform Alpha: Mitochondrion membrane; Single-pass membrane protein. Cytoplasm.

Intact BH3 motif is required by BIK BID BAK BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family By similarity. Sequence similaritiesBelongs to the Bcl-2 family. [1] \" The collagenase gene family in humans consists of at least four members. \" Muller D. Quantin B. Gesnel M. -C. Millon-Collard R. Abecassis J. Breathnach R. Biochem. J. 253:187-192(1988) [PubMed: 2844164] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA]. [2] \" Molecular characterization of a low-molecular-mass matrix metalloproteinase secreted by glomerular mesangial cells as PUMP-1. \" Marti H. P. McNeil L. Thomas G. Davies M. Lovett D. H. Biochem. J. 285:899-905(1992) [PubMed: 1497627] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Kidney. [3] \" Structure and expression of the human gene for the matrix metalloproteinase matrilysin. \" Gaire M. Magbanua Z. McDonnell S. McNeil L. B. Lovett D. H. Matrisian L. M. J. Biol. Chem. 269:2032-2040(1994) [PubMed: 8294454] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Placenta. [4] NIEHS SNPs programSubmitted (OCT-2004) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] VARIANTS HIS-77; ASP-137 AND LEU-241. [5] \" The status quality and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). \" The MGC Project TeamGenome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Colon. [6] \" Purification and characterization of extracellular matrix-degrading metalloproteinase matrin (pump-1) secreted from human rectal carcinoma cell line. \" Miyazaki K. Hattori Y. Umenishi F. Yasumitsu H. Umeda M. Cancer Res. 50:7758-7764(1990) [PubMed: 2253219] [Abstract]Cited for: PROTEIN SEQUENCE OF 18-42. [7] \" Pump-1 cDNA codes for a protein with characteristics similar to those of classical collagenase family members. \" Quantin B. Murphy G. Breathnach R. Biochemistry 28:5327-5334(1989) [PubMed: 2550050] [Abstract]Cited for: FUNCTION. [8] \" Matrilysin-inhibitor complexes: common themes among metalloproteases. \" Browner M. F. Smith W. W. Castelhano A. L. Biochemistry 34:6602-6610(1995) [PubMed: 7756291] [Abstract]Cited for: X-RAY CRYSTALLOGRAPHY (2. 3 ANGSTROMS).