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Human Apolipoprotein B

Human Apolipoprotein B

ArtNr	20-511-241986
Hersteller	GENWAY
Menge	1 mg
Kategorie	Metabolism Glucose Homeostasis Cholesterol & Lipid Metabolism Antibodies Obesity Lipid & Fatty Acid Transport Primary Antibodies
Typ	Antibody
Clon	1606
Specific against	Human
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-49EF68
Similar products	20-511-241986
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Genway ID:	GWB-49EF68
Isotype:	IgG2a
Clone:	1606Host Animal: Mouse. Hybridization of P3X63-Ag8. 653
Type of Product:	Monoclonal Antibodies to Lipoproteins
Concentration:	5. 56mg/ml (OD280nm E1% = 14)Preservatives: NaN3
Buffer:	0. 015M potassium phosphate buffer 0. 15M Sodium chloride pH 7. 2. Applications Notes : Suitable for use in competitive EIA or RIA. Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.
Warning:	This product contains sodium azide which has been classified as Xn (Harmful) in European Directive 67/548/EEC in the concentration range of 0. 1â ??1. 0%. When disposing of this reagent through lead or copper plumbing flush with copious volumes of water to prevent azide build-up in drains. MAb to Human Apolipoprotein B. Monoclonal Antibody to Human Apolipoprotein B (Apo B)
Function:	Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48) LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor.
Subcellular Location:	Secreted.
Ptm:	Palmitoylated; structural requirement for proper assembly of the hydrophobic core of the lipoprotein particle. Rna Editing: Modified_positions=2180; Note=The stop codon (UAA) at position 2180 is created by RNA editing. Apo B-48 derived from the fully edited RNA is produced only in the intestine and is found in chylomicrons. Apo B-48 is a shortened form of apo B-100 which lacks the LDL-receptor region. The unedited version (apo B-100) is produced by the liver and is found in the VLDL and LDL.
Disease:	Defects in APOB are a cause of familial hypobetalipoproteinemia (FHBL) [MIM:107730]. FHBL is a genetically heterogeneous autosomal co-dominant disorder associated with reduced plasma concentrations of apoB LDL and VLDL. Heterozygotes for FHBL are usually asymptomatic with LDL cholesterol and apoB-100 concentrations less than 50% of those in normal plasma. Homozygotes have extremely low plasma LDL cholesterol and apoB-100 concentrations and clinical presentation may vary from no symptoms to severe gastrointestinal and neurological dysfunction similar to abetalipoproteinemia [MIM:200100].
Disease:	Defects in APOB are a cause of familial ligand-defective apolipoprotein B-100 (FDB) [MIM:144010]. FDB is a dominantly inherited disorder of lipoprotein metabolism leading to hypercholesterolemia and increased proneness to coronary artery disease (CAD). The plasma cholesterol levels are dramatically elevated due to impaired clearance of LDL particles by defective APOB/E receptors.
Disease:	Defects in APOB associated with defects in other genes (polygenic) can contribute to hypocholesterolemia.
Similarity:	Contains 1 vitellogenin domain.

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Menge: 1 mg

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