RABBIT ANTI HUMAN TRPA1

GWB-3E2B96

Polyclonal IgG

Detects Transient receptor potential A1 (TRPA1) an excitatory cation channel that is highly expressed in nociceptive neurons and plays an important role in inflammatory pain. TRPA1 mediates the response to the proalgesic bradykinin as well as to pungent irritants found in mustards garlic and cinnamon. TRPA1 may also be involved in hearing (as the mammalian hair cell mechanotransducer) and in the detection of cold stimuli. Recommended Secondary Antibodies: Sheep Anti Rabbit IgGGoat Anti Rabbit IgG (Fc)Goat Anti Rabbit IgG (H/L)

molecular cloning chromosome assignment and cell surface expression. \" Sewell W. A. Brown M. H. Fink P. J. Kozak C. A. Crumpton M. J. Eur. J. Immunol. 17:1015-1020(1987) [PubMed: 2440689] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: B10. A. [2] \" Murine and human T11 (CD2) cDNA sequences suggest a common signal transduction mechanism. \" Clayton L. K. Sayre P. H. Novotny J. Reinherz E. L. Eur. J. Immunol. 17:1367-1370(1987) [PubMed: 2820751] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA]. [3] \" Exon-intron organization and sequence comparison of human and murine T11 (CD2) genes. \" Diamond D. J. Clayton L. K. Sayre P. H. Reinherz E. L. Proc. Natl. Acad. Sci. U. S. A. 85:1615-1619(1988) [PubMed: 2894031] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: BALB/c. Tissue: Liver. [4] \" Molecular cloning of the murine homologue of CD2. Homology of the molecule to its human counterpart T11. \" Yagita H. Okumura K. Nakauchi H. J. Immunol. 140:1321-1326(1988) [PubMed: 3257775] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA]. [5] \" The status quality and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). \" The MGC Project TeamGenome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6. Tissue: Hematopoietic. [6] \" A novel adaptor protein orchestrates receptor patterning and cytoskeletal polarity in T-cell contacts. \" Dustin M. L. Olszowy M. W. Holdorf A. D. Li J. Bromley S. Desai N. Widder P. Rosenberger F. van der Merwe P. A. Allen P. M. Shaw A. S. Cell 94:667-677(1998) [PubMed: 9741631] [Abstract]Cited for: INTERACTION WITH CD2AP. [7] \" The Wiskott-Aldrich syndrome protein acts downstream of CD2 and the CD2AP and PSTPIP1 adaptors to promote formation of the immunological synapse. \" Badour K. Zhang J. Shi F. McGavin M. K. H. Rampersad V. Hardy L. A. Field D. Siminovitch K. A. Immunity 18:141-154(2003) [PubMed: 12530983] [Abstract]Cited for: INTERACTION WITH PSTPIP1.