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GOAT ANTI HUMAN ADIPOR2 (N-TERMINAL)

GOAT ANTI HUMAN ADIPOR2 (N-TERMINAL)

Hersteller	GENWAY
Kategorie	Oncology Metabolism Antibodies Obesity Western Blot Primary Antibodies By Organ Colorectal Cancer
Typ	Antibody
Specific against	Human
Applikationen	WB
Menge	0.1 mg
Host	Goat
ArtNr	18-783-313656
eClass 6.1	32160702
eClass 9.0	32160702
Lieferbar
Alias	GWB-58E274
Genway ID:	GWB-58E274
Specificity:	ADIPOR2 (N-TERMINAL)
Isotype:	Polyclonal IgGSpecies Cross Reactivity: Based on sequence similarity is expected to react with:Mouse RatN. B. Antibody reactivity and working conditions may vary between species.
Buffer Solution:	10mM KHPO4 140mM NaCl pH7. 2
Preservative Stabilisers:		0. 09% Sodium Azide (NaN3) 0. 1% Bovine Serum AlbuminApprox. Protein Concentrations: IgG concentration 1. 0mg/ml
Immunogen:	Synthetic peptide CSRTPEPDIRLRKGHQLDGTRRGDNDSHQG corresponding to amino acids 11-40 within the N-terminal region of human AdipoR2.
Specificity:	Specifically recognises an epitope within the N-terminal (NT) region of Adiponectin Receptor protein 2 (AdipoR2) a transmembrane protein and member of the ADIPOR family expressed mainly in the liver and skeletal muscle which acts a receptor for both globular and full-length adiponectin. AdipoR2 acts as a mediator of fatty acid oxidation glucose uptake by adiponectin and increased AMPK PPARalpha ligand activity thereby playing an important role in the regulation of glucose and lipid metabolism and in oxidative stress.
Specificity:	Is reported as suitable for use in immunocytochemistry on acetone fixed cells. Recommended Secondary Antibodies: Rabbit Anti Goat IgG (Fc)
Function:	Receptor for globular and full-length adiponectin (APM1) an essential hormone secreted by adipocytes that acts as an antidiabetic. Probably involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation. Mediates increased AMPK PPARA ligand activity fatty acid oxidation and glucose uptake by adiponectin. Has some intermediate-affinity receptor activity for both globular and full-length adiponectin. Ref. 5Subunit structureMay form homo and heteromultimers. Ref. 5Subcellular locationMembrane; Multi-pass membrane protein.
Note:	Localized to the cell membrane and intracellular organelles. Ref. 5Tissue specificityHighly expressed in skeletal muscle liver and placenta. Weakly expressed in brain heart colon spleen kidney thymus small intestine peripheral blood leukocytes and lung. Ref. 5Ref. 1
Domain:	The N-terminus is known to be cytoplasmic while the C-terminus is known to be extracellular. Sequence similaritiesBelongs to the ADIPOR family. Sequence cautionThe sequence BAB15062. 1 differs from that shown. Reason: Erroneous initiation.

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Menge: 0.1 mg

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Lieferung vsl. bis 26.07.2024

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