TFF3, Human

ArtNr	Z02904-1
Hersteller	GenScript
Menge	1 mg
Quantity options	1 mg 20 ug
Kategorie	Oncology Neuroscience Neural Lineage Markers Peptides & Proteins Recombinant Proteins Cell Biology Cell Movement Cell Migration & Invasion By Organ Uterine, Ovarian & Cervical Cancer
Typ	Proteins
Specific against	Human (Homo sapiens)
Purity	>95% by SDS-PAGE and HPLC analyses.
Sequence	EEYVGLSANQ CAVPAKDRVD CGYPHVTPKE CNNRGCCFDS RIPGVPWCFK PLQEAECTF
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	protein/Z02904-Trefoil_Factor_3_Human_TFF3_Human, The Trefoil Factor peptides (TFF1, TFF2 and TFF3) are secreted in the gastrointestinal tract, and appear to play an important role in intestinal mucosal defense and repair. TFF-3 is expressed by goblet cells and in the uterus, and has also been shown to express in certain cancers, including colorectal, hepatocellular, and in biliary tumors. TFF3 may be useful as a molecular marker for certain types of cancer, but its role, if any, in tumorigenesis is unknown. TFF3 also promotes airway epithelial cell migration and differentiation.</td></tr><tr><th>M.W.</th><td colspan="7"> Approximately 6.5 kDa, a single non-glycosylated polypeptide chain containing 59 amino acids, which includes a 40-amino acid trefoil motif containing three conserved intramolecular disulfide bonds.</td></tr><tr><th>Purity</th><td colspan="7"> >95% by SDS-PAGE and HPLC analyses.</td></tr><tr><th>Endotoxin Level</th><td colspan="7"> Less than 0.2EU/ug of rHuTFF3 as determined by LAL method.</td></tr><tr><th>Specific Activity</th><td colspan="7"> Fully biologically active when compared to standard. The ED50 determined by a chemotaxis bioassay using human MCF-7 cells is less than 10000 ng/ml, corresponding to a specific activity of &
Similar products	Trefoil
Versandbedingung	Gekühlt
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Specificity	Fully biologically active when compared to standard. The ED50 determined by a chemotaxis bioassay using human MCF-7 cells is less than 10000 ng/ml, corresponding to a specific activity of ＞, 1.0 x 102 IU/mg.
Manufacturer - Category	Proteins
Country of Origin	USA
Shipping Temperature	4°C
Storage Conditions	-80°C
Molecular Weight	Approximately 6.5 kDa, a single non-glycosylated polypeptide chain containing 59 amino acids, which includes a 40-amino acid trefoil motif containing three conserved intramolecular disulfide bonds.
Product Line	Cytokines
Manufacturer - Specificity	Fully biologically active when compared to standard. The ED50 determined by a chemotaxis bioassay using human MCF-7 cells is less than 10000 ng/ml, corresponding to a specific activity of ＞, 1.0 x 102 IU/mg.
Description	The Trefoil Factor peptides (TFF1, TFF2 and TFF3) are secreted in the gastrointestinal tract, and appear to play an important role in intestinal mucosal defense and repair. TFF-3 is expressed by goblet cells and in the uterus, and has also been shown to express in certain cancers, including colorectal, hepatocellular, and in biliary tumors. TFF3 may be useful as a molecular marker for certain types of cancer, but its role, if any, in tumorigenesis is unknown. TFF3 also promotes airway epithelial cell migration and differentiation.
Reconstitution	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at <-20℃, . Further dilutions should be made in appropriate buffered solutions.
Formulation	Lyophilized from a 0.2um filtered concentrated solution in PBS, pH 7.4.
Endotoxin Level	Less than 0.2EU/ug of rHuTFF3 as determined by LAL method.

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