EGF, Human

Epidermal Growth Factor (EGF), is a potent growth factor that stimulates the proliferation of various epidermal and epithelial cells. Additionally, EGF has been shown to inhibit gastric secretion, and to be involved in wound healing. EGF signals through a receptor known as c-erbB, which is a class I tyrosine kinase receptor. This receptor also binds with TGF-alpha and VGF (vaccinia virus growth factor). Recombinant human EGF is a 6.2 kDa globular protein containing 53 amino acid residues including 3 intramolecular disulfide-bonds. Recombinant human Epidermal Growth Factor (rhEGF) produced in E. coli is a non-glycosylated polypeptide chain of 54 amino acids. A fully biologically active molecule, rhEGF has a molecular mass of 6.2kDa analyzed by reducing SDS-PAGE and is obtained by proprietary refolding and chromatographic techniques at GenScript.

Lyophilized after extensive dialysis against 10 mM PB, pH 7.0.

Cytokine, Chemokines & Growth Factors

Lyophilized recombinant human Epidermal Growth Factor (rhEGF), remains stable up to 12 months at -80C from date of receipt. Upon reconstitution, rhEGF should be stable up to 4 weeks at 4C or up to 6 months at -20C.

Growth Factors