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IL-16, Human

IL-16, Human

ArtNr	Z02196-50
Hersteller	GenScript
Menge	50 ug
Quantity options	1 mg 10 ug 50 ug
Kategorie	Oncology Food Safety Neuroscience Neural Lineage Markers Aging & Neurological Disorders By Cell Type Carcinoma Melanoma Peptides & Proteins Recombinant Proteins Cell Biology Cell Movement Cell Adhesion Cell Culture Cytokines Adenocarcinoma Contaminants Cell Migration & Invasion Metals By Organ Breast Cancer Heart & Blood Cancer
Typ	Proteins
Specific against	Human (Homo sapiens)
Purity	Greater than 97.0% as determined by (a) RP-HPLC analysis, (b) Anion-exchange FPLC (c) Reducing and non-reducing SDS-PAGE Silver Stained gel analysis
Sequence	The sequence of the first five N-terminal amino acids was determined and was found to be Met-Pro-Asp-Leu-Asn.
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	protein/Z02196-Interleukin_16_IL_16_human, IL-16 is a CD8+ T cell-derived cytokine that induces chemotaxis of CD4+ T cells and CD4+ monocytes and eosinophils. Analysis by gel filtration suggests that, under physiological conditions, human IL-16 exists predominantly as a noncovalently linked multimer, but that some IL-16 may exist as a monomer. However, only the multimeric form appears to possess chemotactic activity, suggesting that receptor cross-linking may be required for activity. IL-16 also induces expression of IL-2 receptor (IL-2R) and MHC class II molecules on CD4+ T cells. Human and murine IL-16 show significant cross-species reactivity. GenScript, Interleukin (IL)-16, human, produced in, E. coli, is a single, non-glycosylated polypeptide chain containing 130 amino acids and having a molecular mass of 13,400 Da.</td></tr><tr><th>M.W.</th><td colspan="7"> 13,400 Da</td></tr><tr><th>Purity</th><td colspan="7"> Greater than 97.0% as determined by (a) RP-HPLC analysis, (b) Anion-exchange FPLC (c) Reducing and non-reducing SDS-PAGE Silver Stained gel analysis</td></tr><tr><th>Endotoxin Level</th><td colspan="7"> Less than 0.1 ng/ug (1 IEU/ug) determined by LAL test</td></tr><tr><th>Storage</th><td colspan="7"> Lyophilized rHuIL-16 although stable at room temperature for 3 weeks, should be stored desiccated below -18C. Upon reconstitution rHuIL-16 should be stored at 4C between 2-7 days and for future use below -18C. For long-term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please avoid freeze-thaw cycles.</td></tr><tr><th>Specificity</th><td colspan="7"> rHuIL-16 is fully biologically active when compared to standard. The ED50 as determined by its ability to chemoattract human CD4+ T lymphocytes using a concentration range of 10.0-100.0 ng/ml, corresponding to a specific activity greater than 1.0×104 IU/mg.</td></tr><tr><th>Formulation</th><td colspan="7"> rHuIL-16 was lyophilized from 1 mg/ml solution after extensive dialysis against 20 mM acetic buffer, pH 5.0, 150 mM NaCl and 0.5 mM DTT.</td></tr><tr><th>Reconstitution</th><td colspan="7"> It is recommended to reconstitute the lyophilized rHuIL-16 in sterile 18 M&
Similar products	Interleukin-16
Versandbedingung	Gekühlt
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Specificity	rHuIL-16 is fully biologically active when compared to standard. The ED50 as determined by its ability to chemoattract human CD4+ T lymphocytes using a concentration range of 10.0-100.0 ng/ml, corresponding to a specific activity greater than 1.0x104 IU/m
Manufacturer - Category	Proteins
Country of Origin	USA
Shipping Temperature	4°C
Storage Conditions	-80°C
Molecular Weight	13, 400 Da
Product Line	Cytokines
Manufacturer - Specificity	rHuIL-16 is fully biologically active when compared to standard. The ED50 as determined by its ability to chemoattract human CD4+ T lymphocytes using a concentration range of 10.0-100.0 ng/ml, corresponding to a specific activity greater than 1.0x104 IU/mg.
Description	IL-16 is a CD8+ T cell-derived cytokine that induces chemotaxis of CD4+ T cells and CD4+ monocytes and eosinophils. Analysis by gel filtration suggests that, under physiological conditions, human IL-16 exists predominantly as a noncovalently linked multimer, but that some IL-16 may exist as a monomer. However, only the multimeric form appears to possess chemotactic activity, suggesting that receptor cross-linking may be required for activity. IL-16 also induces expression of IL-2 receptor (IL-2R) and MHC class II molecules on CD4+ T cells. Human and murine IL-16 show significant cross-species reactivity. GenScript, Interleukin (IL)-16, human, produced in, E. coli, is a single, non-glycosylated polypeptide chain containing 130 amino acids and having a molecular mass of 13, 400 Da.
Reconstitution	It is recommended to reconstitute the lyophilized rHuIL-16 in sterile 18 MΩ, -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
Formulation	rHuIL-16 was lyophilized from 1 mg/ml solution after extensive dialysis against 20 mM acetic buffer, pH 5.0, 150 mM NaCl and 0.5 mM DTT.
Endotoxin Level	Less than 0.1 ng/ug (1 IEU/ug) determined by LAL test

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Menge: 50 ug

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