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IL-15, Human Europäischer Partner

ArtNr Z00377-1
Hersteller GenScript
Menge 1 mg
Kategorie
Typ Proteins
Specific against Human
Purity Greater than 98.0% as determined by: (a)Analysis by RP-HPLC (b)Anion-exchange FPLC (c)Analysis by reducing and non-reducing SDS-PAGE Silver Stained gel.
Sequence MNWVNVISDL KKIEDLIQSM HIDATLYTES DVHPSCKVTA MKCFLLELQV ISHESGDTDI HDTVENLIIL ANNILSSNGN ITESGCKECE ELEEKNIKEF LQSFVHIVQM FINTS
Citations Suzuki A, et al . Interleukin-15 increases hepatic regenerative activity. J. Hepatol. Sep 2006, 45 (3): 410-418. Lin SJ, et al . Effect of interleukin-15 on alloreactivity in umbilical cord blood. Transpl. Immunol. Aug 2006, 16 (2): 112-116. Waldmann TA. The biology of interleukin-2 and interleukin-15: implications for cancer therapy and vaccine design. Nat. Rev. Immunol. Aug 2006, 6 (8): 595-601.
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Alias protein/Z00377_1-Interleukin_15_IL_15_Human,Interleukin 15 (IL-15), is a cytokine that possesses a variety of biological functions. Interleukin 15 (IL-15) stimulates the proliferation of T-lymphocytes, which requires interaction of IL-15 with components of IL-2R, including IL-2R and probably IL-2R gamma, but not IL-2R. Recombinant human Interleukin 15 (IL-15), produced in, E. coli, is a single, non-glycosylated polypeptide chain containing 114 amino acids and having a molecular mass of 12,774 Da.</td></tr><tr><th>M.W.</th><td colspan="7"> 12,774 Da</td></tr><tr><th>Purity</th><td colspan="7"> Greater than 98.0% as determined by: (a)Analysis by RP-HPLC (b)Anion-exchange FPLC (c)Analysis by reducing and non-reducing SDS-PAGE Silver Stained gel.</td></tr><tr><th>Endotoxin Level</th><td colspan="7"> Less than 0.1 ng/ug (1 EU/ug) of recombinant human Interleukin-15 (IL-15) as determined by LAL test.</td></tr><tr><th>Specific Activity</th><td colspan="7"> The ED50 as determined by the dose-dependant stimulation of the proliferation of CTLL-2 was found to be <0.5 ng/ml, corresponding to a Specific Activity of 2x106 IU/mg.</td></tr><tr><th>Storage</th><td colspan="7"> Lyophilized, recombinant human Interleukin 15 (IL-15), remains stable at room temperature for three weeks, but it is best stored desiccated below -18C. Upon reconstitution recombinant human Interleukin 15 (IL-15) should be stored at 4C for up to seven days. For long term storage it is recommended that a carrier protein (0.1% HSA or BSA ) be added. Avoid repeated freeze-thaw cycles.</td></tr><tr><th>Formulation</th><td colspan="7">Recombinant human Interleukin-15 (IL-15), was lyophilized after extensive dialysis against 20mM PB, pH7.5, 150mM NaCl buffer.</td></tr><tr><th>Reconstitution</th><td colspan="7"> It is recommended to reconstitute the lyophilized, Recombinant Human Interleukin 15 (IL-15), in sterile 18 Momega-cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.</td></tr><tr><th>Sequence</th><td colspan="7"> MNWVNVISDL KKIEDLIQSM HIDATLYTES DVHPSCKVTA MKCFLLELQV ISHESGDTDI HDTVENLIIL ANNILSSNGN ITESGCKECE ELEEKNIKEF LQSFVHIVQM FINTS </td></tr><tr><th>Reference</th><td colspan="7">Suzuki A, et al . Interleukin-15 increases hepatic regenerative activity. J. Hepatol. Sep 2006, 45 (3): 410-418. Lin SJ, et al . Effect of interleukin-15 on alloreactivity in umbilical cord blood. Transpl. Immunol. Aug 2006, 16 (2): 112-116. Waldmann TA. The biology of interleukin-2 and interleukin-15: implications for cancer therapy and vaccine design. Nat. Rev. Immunol. Aug 2006, 6 (8): 595-601.</td></tr>
Similar products Interleukin-15
Lieferbar
Specificity The ED50 as determined by the dose-dependant stimulation of the proliferation of CTLL-2 was found to be <0.5 ng/ml, corresponding to a Specific Activity of 2x106 IU/mg.
Specificity
The ED50 as determined by the dose-dependant stimulation of the proliferation of CTLL-2 was found to be <0.5 ng/ml, corresponding to a Specific Activity of 2x106 IU/mg.
Description
Interleukin 15 (IL-15), is a cytokine that possesses a variety of biological functions. Interleukin 15 (IL-15) stimulates the proliferation of T-lymphocytes, which requires interaction of IL-15 with components of IL-2R, including IL-2R and probably IL-2R gamma, but not IL-2R. Recombinant human Interleukin 15 (IL-15), produced in, E. coli, is a single, non-glycosylated polypeptide chain containing 114 amino acids and having a molecular mass of 12, 774 Da.
Endotoxin Level
Less than 0.1 ng/ug (1 EU/ug) of recombinant human Interleukin-15 (IL-15) as determined by LAL test.
Formulation
Recombinant human Interleukin-15 (IL-15), was lyophilized after extensive dialysis against 20mM PB, pH7.5, 150mM NaCl buffer.
M.W.
12, 774 Da
Product Line
Cytokine, Chemokines & Growth Factors
Reconstitution
It is recommended to reconstitute the lyophilized, Recombinant Human Interleukin 15 (IL-15), in sterile 18 Momega-cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
Storage
Lyophilized, recombinant human Interleukin 15 (IL-15), remains stable at room temperature for three weeks, but it is best stored desiccated below -18C. Upon reconstitution recombinant human Interleukin 15 (IL-15) should be stored at 4C for up to seven days. For long term storage it is recommended that a carrier protein (0.1% HSA or BSA ) be added. Avoid repeated freeze-thaw cycles.
Manufacturers Category
Proteins
Manufacturers Product Line
Cytokines
Product Origin
USA

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Menge: 1 mg
Lieferbar: In stock
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