ArtNr |
A01566 |
Hersteller |
GenScript
|
Menge |
100ug |
Kategorie |
|
Typ |
Antibody Monoclonal |
Applikationen |
IHC, ELISA, other, Dot |
Specific against |
Human |
Host |
Mouse |
Isotype |
IgG2b Kappa |
Konjugat/Tag |
Unconjugated |
ECLASS 10.1 |
42030590 |
ECLASS 11.0 |
42030590 |
UNSPSC |
12352203 |
Alias |
A01566-Human_Amyloid_1_40_Antibody_4A4F2_mAb_Mouse,Human beta-Amyloid 1-40 Antibody (4A4F2), mAb, Mouse |
Similar products |
GenScript |
Lieferbar |
|
Specificity |
GenScript Human beta-Amyloid 1-40 Antibody (4A4F2), mAb, Mouse, detects human beta-Amyloid 1-40 and does not cross-react with human beta-Amyloid 1-42. |
Specificity |
GenScript Human beta-Amyloid 1-40 Antibody (4A4F2), mAb, Mouse, detects human beta-Amyloid 1-40 and does not cross-react with human beta-Amyloid 1-42. |
Concentration |
0.5 mg/ml, lyophilized with PBS, pH 7.4, containing 0.02% sodium azide. |
Description |
A number of mutations, identified in the gene encoding the beta-amyloid precursor protein (betaAPP), have been linked to early-onset Familial Alzheimer's Disease. betaAPP is cleaved sequentially by the proteolytic enzymes beta-secretase and gamma-secretase to produce beta-amyloid (Abeta) peptides with the Abeta1-42(43) and the Abeta1-40 forms being the most prevalent. Secreted Abeta peptides can bind to scavenger receptors and the receptor for advanced glycation end- products. Abeta peptides are degraded either via a reuptake mechanism followed by endosomal degradation or by an extracellular insulin-degrading enzyme. Extracellular accumulation of Abeta leads to formation of aggregates, fibrils and eventually amyloid deposits called neuritic plaques, a hallmark of Alzheimer’s disease. beta-amyloid antibodies and peptides have been developed as tools for elucidating the biology of Alzheimer's disease. |
Fusion Partner |
Spleen cells were fused with SP2/0-Ag14 mouse myeloma cells. |
Immunogen |
synthetic peptide corresponding to amino acids 32-40 of beta-Amyloid C-terminus conjugated to KLH (Swiss Prot: P05067) |
Purification Method |
Protein A affinity column |
Reconstitution |
Reconstitute lyophilized powder with deionized water (or equivalent) to antibody concentration of 0.5 mg/ml. |
Species Reactivity |
Human. Reactivity to other species is not tested yet. |
Storage |
GenScript Human beta-Amyloid 1-40 Antibody (4A4F2), mAb, Mouse, should be stored lyophilized until use. It remains stable in lyophilized form if stored at -20C or below. The reconstituted antibody can be stored for 2-3 weeks at 2-8C or for up to 12 months at -20C or below. Avoid repeated freezing and thawing cycles. |
Product Origin |
USA |
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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.