ArtNr |
ELS-PKSR030452-10ug |
Hersteller |
Elabscience
|
Menge |
10ug |
Kategorie |
|
Typ |
Proteins |
Specific against |
Rat |
Host |
E.coli |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Alias |
FPH2, KIT ligand, Kitl, KITLG, KL-1, Mast cell growth factor, MGF, MGFSHEP7, SCF, SFc-Kit ligand, SLF, steel factor, Stem Cell Factor, c-kit Ligand |
Similar products |
SCF, KITLG, Stem Cell Factor, MGF, Kitl, Mast cell growth factor, FPH2, KL-1, steel factor, SLF, KIT ligand, MGFSHEP7, SFc-Kit ligand, c-kit Ligand |
Lieferbar |
|
Synonym |
FPH2, KIT ligand, Kitl, KITLG, KL-1, Mast cell growth factor, MGF, MGFSHEP7, SCF, SFc-Kit ligand, SLF, steel factor, Stem Cell Factor, c-kit Ligand |
Storage |
according to manual |
Protein Construction |
Recombinant Rat Stem Cell Factor is produced by our E.coli expression system and the target gene encoding Gln26-Ala189 is expressed with a 6His tag at the C-terminus. |
Sequence |
Gln26-Ala189 |
Fusion tag |
C-6His |
Accession |
P21581 |
Shipping |
This product is provided as lyophilized powder which is shipped with ice packs. |
Purity |
> 95 % as determined by SDS-PAGE |
Endotoxin |
<1.0 EU per ug as determined by LAL test. |
Stability and Storage |
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80CC. Reconstituted protein solution can be stored at 4-8C for 2-7 days. Aliquots of reconstituted samples are stable at < -20C for 3 months. |
Mol Mass |
19.3 kDa |
AP Mol Mass |
19.3 kDa |
Formulation |
Lyophilized from a 0.2 um filtered solution of PBS, pH7.4. |
Reconstitution |
Please refer to the printed manual for detailed information. |
Background |
Stem cell factor (SCF), is the ligand for the receptor-type protein-tyrosine kinase KIT. It plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. It also promotes phosphorylation of PIK3R1, which is the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. |
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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.