Recombinant Cynomolgus B7-1/CD80 Protein (Fc Tag)

T-lymphocyte activation antigen CD80, Activation B7-1 antigen, B7, CD80

Recombinant Cynomolgus CD80 is produced by our Mammalian expression system and the target gene encoding Val35-Asn242 is expressed with a Fc tag at the C-terminus.

C-Fc

This product is provided as lyophilized powder which is shipped with ice packs.

< 1.0 EU per ug as determined by the LAL method.

51 kDa

Lyophilized from a 0.2 um filtered solution of 50 mM Tris, 100 mM Glycine, pH 7.5.

Cynomologous Cluster of Differentiation 80, also called B7-1, is a member of cell surface immunoglobulin superfamily.It is expressed on the surface of antigen-presenting cells including activated B cells, macrophages and dendritic cells.CD80 plays key, yet distinct roles in the activation of T cells. B7-1/CD80 and B7-2/CD86, together with their receptors CD28 and CTLA4, constitute one of the dominant co-stimulatory pathways that regulate T- and B- cell responses. CD80 is mostly expressed on the surface of antigen-presenting cells including activated B cells, macrophages and dendritic cells. Although both CTLA-4 and CD28 can bind to the same ligands, CTLA-4 binds to B7-1 and B7-2 with a 20-100 fold higher affinity than CD28 and is involved in the down-regulation of the immune response. CD80 is thus regarded as promising therapeutic targets for autoimmune diseases and various carcinomas.