Hersteller |
Elabscience
|
Kategorie |
|
Typ |
Proteins |
Specific against |
Mouse |
Menge |
50ug |
Host |
Human Cells |
ArtNr |
ELS-PKSM041165-50ug |
eClass 6.1 |
34160400 |
eClass 9.0 |
42020190 |
Lieferbar |
|
Alias |
Tumor necrosis factor ligand superfamily member 11,Tnfsf11,Osteoclast differentiation factor,ODF,Osteoprotegerin ligand,OPGL,Receptor activator of nuclear factor kappa-B ligand,RANKL,TNF-related activation-induced cytokine,TRANCE,CD254 |
Synonym |
Tumor necrosis factor ligand superfamily member 11, Tnfsf11, Osteoclast differentiation factor, ODF, Osteoprotegerin ligand, OPGL, Receptor activator of nuclear factor kappa-B ligand, RANKL, TNF-related activation-induced cytokine, TRANCE, CD254 |
Storage |
according to manual |
Activity |
Immobilized Human OPG-Fc(Cat: PKSH033124) at 2ug/ml(100 ul/well) can bind Mouse RANKL-His. The ED50 of Mouse RANK L-His is 2.44ug/ml . |
Protein Construction |
Recombinant Mouse TNF-related Activation-induced Cytokine is produced by our Mammalian expression system and the target gene encoding Ala73-Asp316 is expressed with a 6His tag at the N-terminus. |
Sequence |
Ala73-Asp316 |
Fusion tag |
C-6His |
Accession |
O35235 |
Shipping |
This product is provided as lyophilized powder which is shipped with ice packs. |
Purity |
> 95 % as determined by SDS-PAGE |
Endotoxin |
< 1.0 EU per ug as determined by the LAL method. |
Stability and Storage |
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80CC. Reconstituted protein solution can be stored at 4-8C for 2-7 days. Aliquots of reconstituted samples are stable at < -20C for 3 months. |
Mol Mass |
28.5 kDa |
AP Mol Mass |
30-35 kDa |
Formulation |
Lyophilized from a 0.2 um filtered solution of 20mM PB, 150mM NaCl, pH 7.4. |
Reconstitution |
Please refer to the printed manual for detailed information. |
Background |
Mouse tumor necrosis factor ligand superfamily member 11(Tnfsf11) is a member of the tumor necrosis factor (TNF) cytokine family. Tnfsf11 is widely expressed in cells including T cells and T cell rich organs, such as thymus and lymph nodes. This cytokine can bind to TNFRSF11B/OPG andTNFRSF11A/RANK. Tnfsf11 is involved in a number of fundamental biological processes such as acting as regulator of interactions between T-cells and dendritic cells, the regulation of the T-cell-dependent immune response and enhancing bone-resorption in humoral hypercalcemia of malignancy. It augments the ability of dendritic cells to stimulate naive T-cell proliferation. |
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