Recombinant Mouse CD64/FCGR1 Protein (His Tag)(Active)

according to manual

A DNA sequence encoding the extracellular domain (Met 1-Pro 297) of mouse FCGR1 (NP_034316.1) precursor was fused with a polyhistidine tag at the C-terminus.

C-His

This product is provided as lyophilized powder which is shipped with ice packs.

< 1.0 EU per ug of the protein as determined by the LAL method.

32 kDa

Lyophilized from sterile PBS, pH 7.4

High affinity immunoglobulin gamma Fc receptor I, also known as FCGR1 and CD64, is an integral membrane  glycoprotein and a member of the immunoglobulin superfamily. CD64 is a high affinity receptor for the Fc region of IgG gamma and functions in both innate and adaptive immune responses. Receptors that recognize the Fc portion of IgG function in the regulation of immune response and are divided into three classes designated CD64, CD32, and CD16. CD64 is structurally composed of a  signal peptide  that allows its transport to the surface of a cell, three  extracellular  immunoglobulin domains  of the C2-type that it uses to bind antibody, a hydrophobic  transmembrane domain, and a short cytoplasmic tail. CD64 is  constitutively  found on only macrophages and monocytes, but treatment of polymorphonuclear leukocytes  with cytokines like  IFNgamma  and  G-CSF  can induce CD64 expression on these cells. The inactivation of the mouse CD64 resulted in a wide range of defects in antibody Fc-dependent functions. Mouse CD64 is an early participant in Fc-dependent cell activation and in the development of immune responses.